WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2011143160) METABOLIC INHIBITOR AGAINST TUMORS HAVING AN IDH MUTATION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/143160    International Application No.:    PCT/US2011/035841
Publication Date: 17.11.2011 International Filing Date: 10.05.2011
IPC:
A61K 31/433 (2006.01), A61P 35/00 (2006.01)
Applicants: THE JOHNS HOPKINS UNIVERSITY [US/US]; 3400 North Charles Street Baltimore, Maryland 21218 (US) (For All Designated States Except US).
RIGGINS, Gregory Joseph [US/US]; (US) (For US Only).
SELTZER, Meghan Joyce [US/US]; (US) (For US Only).
TSUKAMOTO, Takashi [JP/US]; (US) (For US Only).
DANG, Chi Van [US/US]; (US) (For US Only).
EMADI, Ashkan [IR/US]; (US) (For US Only)
Inventors: RIGGINS, Gregory Joseph; (US).
SELTZER, Meghan Joyce; (US).
TSUKAMOTO, Takashi; (US).
DANG, Chi Van; (US).
EMADI, Ashkan; (US)
Agent: CHILDERS, Jeffrey W.; 100 N. Charles Street 5th Floor Baltimore, Maryland 21201 (US)
Priority Data:
61/333,010 10.05.2010 US
61/357,674 23.06.2010 US
61/383,426 16.09.2010 US
Title (EN) METABOLIC INHIBITOR AGAINST TUMORS HAVING AN IDH MUTATION
(FR) INHIBITEUR MÉTABOLIQUE CONTRE DES TUMEURS AYANT UNE MUTATION DE L'IDH
Abstract: front page image
(EN)Methods for treating a cancer having a mutant isocitrate dehydrogenase (IDH), including, but not limited to, a malignant low-grade glioma, a secondary glioblastoma, a transforming myeloproliferative disorder (tMPD), and an acute myelogenous leukemia (AML), with a glutaminase inhibitor, including, bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES), are disclosed.
(FR)La présente invention a pour objet des méthodes de traitement d'un cancer comportant une isocitrate déshydrogénase (IDH) mutante, comprenant, mais sans limitation, un gliome malin de grade inférieur, un glioblastome secondaire, un trouble myéloprolifératif transformant (tMPD), et une leucémie myélogène aiguë (AML), avec un inhibiteur de la glutaminase, comprenant du sulfure de bis-2-(5-phénylacétamido-1,2,4-thiadiazol-2-yle) éthyle (BPTES).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)