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1. (WO2011143124) ENDORIBONUCLEASE COMPOSITIONS AND METHODS OF USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/143124    International Application No.:    PCT/US2011/035775
Publication Date: 17.11.2011 International Filing Date: 09.05.2011
IPC:
C12N 9/22 (2006.01), C12N 15/55 (2006.01), C12Q 1/34 (2006.01), C12Q 1/68 (2006.01), G01N 33/573 (2006.01)
Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 1111 Franklin Street, Twelfth Floor Oakland, California 94607-5200 (US) (For All Designated States Except US).
HAURWITZ, Rachel E. [US/US]; (US) (For US Only).
DOUDNA, Jennifer A. [US/US]; (US) (For US Only).
WIEDENHEFT, Blake [US/US]; (US) (For US Only).
JINEK, Martin [CZ/US]; (US) (For US Only)
Inventors: HAURWITZ, Rachel E.; (US).
DOUDNA, Jennifer A.; (US).
WIEDENHEFT, Blake; (US).
JINEK, Martin; (US)
Agent: BORDEN, Paula A.; Bozicevic, Field & Francis LLP 1900 University Avenue Suite 200 East Palo Alto, California 94303 (US)
Priority Data:
61/333,163 10.05.2010 US
61/365,627 19.07.2010 US
61/413,287 12.11.2010 US
Title (EN) ENDORIBONUCLEASE COMPOSITIONS AND METHODS OF USE THEREOF
(FR) COMPOSITIONS D'ENDORIBONUCLÉASES ET LEURS PROCÉDÉS D'UTILISATION
Abstract: front page image
(EN)The present disclosure provides variant Csy4 endoribonucleases, nucleic acids encoding the variant Csy4 endoribonucleases, and host cells genetically modified with the nucleic acids. The variant Csy4 endoribonucleases find use in a variety of applications, which are also provided. The present disclosure also provides methods of detecting a specific sequence in a target polyribonucleotide; and methods of regulating production of a target RNA in a eukaryotic cell.
(FR)La présente invention concerne des variants d'endoribonucléases Csy4, des acides nucléiques codant pour ces variants, et des cellules hôtes génétiquement modifiées avec les acides nucléiques. L'invention concerne également les diverses applications dans lesquelles les variants d'endoribonucléases Csy4 trouvent une utilisation, des procédés de détection d'une séquence spécifique dans un polyribonucléotide cible, et des procédés de régulation de la production d'un ARN cible dans une cellule eucaryote.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)