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Machine translation
1. (WO2011142952) METHOD OF DETECTING AND PROFILING PROGRESSION OF THE RISK OF NEURODEGENERATIVE DISEASES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/142952    International Application No.:    PCT/US2011/033387
Publication Date: 17.11.2011 International Filing Date: 21.04.2011
IPC:
G01N 33/48 (2006.01), G01N 33/53 (2006.01)
Applicants: ANN AND ROBERT H. LURIE CHILDREN'S HOSPITAL OF CHICAGO [US/US]; 225 E. Chicago Ave. Chicago, IL 60601 (US) (For All Designated States Except US).
MAYANIL, C., Shekhar [US/US]; (US) (For US Only).
ICHI, Shunsuke [JP/US]; (US) (For US Only).
TOMITA, Tadanori [US/US]; (US) (For US Only)
Inventors: MAYANIL, C., Shekhar; (US).
ICHI, Shunsuke; (US).
TOMITA, Tadanori; (US)
Agent: MURRAY, John; Brinks Hofer Gilson & Lione P.o. Box 10087 Chicago, IL 60610 (US)
Priority Data:
61/395,321 11.05.2010 US
Title (EN) METHOD OF DETECTING AND PROFILING PROGRESSION OF THE RISK OF NEURODEGENERATIVE DISEASES
(FR) MÉTHODES DE DÉPISTAGE ET DE PROFILAGE DE L'ÉVOLUTION DU RISQUE DES MALADIES NEURODÉGÉNÉRATIVES
Abstract: front page image
(EN)The present invention generally relates to methods of detecting and profiling progression of the risk of neurodegenerative diseases in a subject. In one embodiment, the method includes isolating a stem cell from cerebrospinal fluid of the subject and determining the level of H3K27 methylation within the stem cell. The subject is determined to have an increased risk of developing the neurodegenerative disease if the level of H3K27 methylation is elevated. In various embodiments, the neurodegenerative disease is A lzheimer's Disease, Parkinson's Disease or Amyotrophic Lateral Sclerosis.
(FR)De manière générale, cette invention concerne des méthodes de dépistage et de profilage de l'évolution du risque des maladies neurodégénératives chez un sujet. Dans un mode de réalisation, la méthode comprend l'isolation d'une cellule souche provenant du liquide céphalorachidien du sujet et la détermination de degré de méthylation de H3K27 au sein de la cellule souche. Le sujet est considéré comme présentant un risque accru de développer une maladie dégénérative si le degré de méthylation de H3K27 est élevé. Dans divers modes de réalisation, la maladie dégénérative est la maladie d'Alzheimer, la maladie de Parkinson ou la sclérose latérale amyotrophique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)