WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2011142716) NOVEL HEMIFUMARATE SALT OF ISOINDOLE COMPOUND ACTING AS BACE INHIBITOR
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/142716    International Application No.:    PCT/SE2011/050592
Publication Date: 17.11.2011 International Filing Date: 11.05.2011
IPC:
C07D 401/14 (2006.01), A61K 31/506 (2006.01), A61P 25/28 (2006.01)
Applicants: ASTRAZENECA AB [SE/SE]; S-151 85 Södertälje (SE) (For All Designated States Except US).
BERGSTRÖM, Per-Olov [SE/SE]; (SE) (For US Only).
MINIDIS, Anna [SE/SE]; (SE) (For US Only).
STRANNE, Robert, Ulf, Johan [SE/SE]; (SE) (For US Only).
WERNERSSON, Mikael [SE/SE]; (SE) (For US Only)
Inventors: BERGSTRÖM, Per-Olov; (SE).
MINIDIS, Anna; (SE).
STRANNE, Robert, Ulf, Johan; (SE).
WERNERSSON, Mikael; (SE)
Agent: ASTRAZENECA INTELLECTUAL PROPERTY; AstraZeneca AB S-151 85 Södertälje (SE)
Priority Data:
61/333,883 12.05.2010 US
Title (EN) NOVEL HEMIFUMARATE SALT OF ISOINDOLE COMPOUND ACTING AS BACE INHIBITOR
(FR) NOUVEAU SEL HÉMIFUMARATE DE COMPOSÉ ISOINDOLE FAISANT OFFICE D'INHIBITEUR DE BACE
Abstract: front page image
(EN)The present invention relates to a hemifumarate salt of the compound (1S)-1-(2- (difluoromethyl)pyridin-4-yl)-4-fluoro-1-(3-(pyrimidin-5-yl)phenyl)-1H-isoindol-3-amine, Form A thereof and its pharmaceutical compositions. In addition, the present invention relates to therapeutic methods for the treatment and/or prevention of Αβ-related pathologies such as Downs syndrome, β-amyloid angiopathy such as but not limited to cerebral amyloid angiopathy or hereditary cerebral hemorrhage, disorders associated with cognitive impairment such as but not limited to MCI ("mild cognitive impairment"), Alzheimer Disease, memory loss, attention deficit symptoms associated with Alzheimer disease, neurodegeneration associated with diseases such as Alzheimer disease or dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease, progressive supranuclear palsy or cortical basal degeneration.
(FR)La présente invention concerne un sel hémifumarate du composé (1S)-1-(2- (difluorométhyl)pyridin-4-yl)-4-fluoro-1-(3-(pyrimidin-5-yl)phényl)-1H-iso-indol-3-amine, sa Forme A et ses compositions pharmaceutiques. En outre, la présente invention concerne des méthodes thérapeutiques pour le traitement et/ou la prévention de pathologies liées à Αβ, comme la syndrome de Down, l'angiopathie β-amyloïde, comme, sans s'y limiter, l'angiopathie amyloïde cérébrale ou l'hémorragie cérébrale héréditaire, des troubles associés à la déficience cognitive, comme, sans s'y limiter, la DCL («déficience cognitive légère»), la maladie d'Alzheimer, la perte de mémoire, les symptômes de déficit de l'attention liés à la maladie d'Alzheimer, la neurodégénérescence associée à des maladies comme la maladie d'Alzheimer ou une démence, notamment la démence mixte d'origine vasculaire et dégénérative, la démence pré-sénile, la démence sénile et la démence associée à la maladie de Parkinson, l'ophtalmoplégie supranucléaire progressive ou la dégénérescence cortico-basale.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)