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1. (WO2011142621) PHARMACEUTICAL FORMULATION IN THE FORM OF BILAYERED TABLETS COMPRISING HMG-COA REDUCTASE INHIBITOR AND IRBESARTAN
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/142621    International Application No.:    PCT/KR2011/003549
Publication Date: 17.11.2011 International Filing Date: 13.05.2011
IPC:
A61K 9/24 (2006.01), A61K 9/20 (2006.01), A61K 31/415 (2006.01), A61K 31/40 (2006.01), A61P 3/06 (2006.01), A61P 3/00 (2006.01)
Applicants: HANMI SCIENCE CO., LTD. [KR/KR]; 550, Dongtangiheung-ro, Dongtan-myeon, Hwaseong-si, Gyeonggi-do 445-813 (KR) (For All Designated States Except US).
KIM, Yong Il [KR/KR]; (KR) (For US Only).
NA, Young Jun [KR/KR]; (KR) (For US Only).
KIM, Min Jung [KR/KR]; (KR) (For US Only).
KIM, Young-Hun [KR/KR]; (KR) (For US Only).
PARK, Jae Hyun [KR/KR]; (KR) (For US Only).
WOO, Jong Soo [KR/KR]; (KR) (For US Only)
Inventors: KIM, Yong Il; (KR).
NA, Young Jun; (KR).
KIM, Min Jung; (KR).
KIM, Young-Hun; (KR).
PARK, Jae Hyun; (KR).
WOO, Jong Soo; (KR)
Agent: FIRSTLAW LEE & KO; Trust Tower, 275-7 Yangjae-Dong, Seocho-Ku Seoul 137-739 (KR)
Priority Data:
10-2010-0045636 14.05.2010 KR
10-2010-0053782 08.06.2010 KR
Title (EN) PHARMACEUTICAL FORMULATION IN THE FORM OF BILAYERED TABLETS COMPRISING HMG-COA REDUCTASE INHIBITOR AND IRBESARTAN
(FR) FORMULATION PHARMACEUTIQUE SOUS LA FORME DE COMPRIMÉS BICOUCHES COMPRENANT UN INHIBITEUR DE HMG-COA RÉDUCTASE ET D'IRBÉSARTAN
Abstract: front page image
(EN)Provided is a pharmaceutical formulation in the form of bilayered tablets consisting of a first layer containing irbesartan or pharmaceutically acceptable salts thereof and a second layer containing an HMG-CoA reductase inhibitor and a basic additive, which can improve the dissolution rate and stability of irbesartan and an HMG-CoA reductase inhibitor to enhance the bioavailability of the drug compared to conventional complex formulations and to minimize the generation of the related compounds, thereby being effectively used as a stable and superior therapeutic agent for hypertension and hypercholesterolemia.
(FR)La présente invention concerne une formulation pharmaceutique sous la forme de comprimés bicouches constitués d'une première couche contenant de l'irbésartan ou des sels pharmaceutiquement acceptables de ceux-ci et une deuxième couche contenant un inhibiteur de HMG-CoA réductase et un additif basique, qui peut améliorer le taux de dissolution et la stabilité d'irbésartan et un inhibiteur de HMG-CoA réductase pour augmenter la biodisponibilité du médicament par rapport à des formulations complexes conventionnelles et réduire au minimum la génération des composés apparentés, de manière à être efficacement utilisé en tant qu'agent thérapeutique stable et supérieur pour l'hypertension et l'hypercholestérolémie.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)