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1. (WO2011142518) SENSOR FOR MEASURING THE CALORIFIC VALUE OF A CELL USING THE ZWEIFACH-FUNG EFFECT, AND METHOD FOR MANUFACTURING SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/142518    International Application No.:    PCT/KR2010/008747
Publication Date: 17.11.2011 International Filing Date: 08.12.2010
IPC:
G01N 33/48 (2006.01), G01N 35/08 (2006.01), G01N 25/20 (2006.01), G01N 27/00 (2006.01)
Applicants: GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY [KR/KR]; 1 Oryong-dong, Buk-gu Gwangju 500-712 (KR) (For All Designated States Except US).
LEE, Sun Kyu [KR/KR]; (KR) (For US Only).
NAM, Sung Ki [KR/KR]; (KR) (For US Only).
JEONG, Su Heon [KR/KR]; (KR) (For US Only).
KIM, Jung Kyun [KR/KR]; (KR) (For US Only).
WOO, Do Kyun [KR/KR]; (KR) (For US Only).
YANG, Sung [KR/KR]; (KR) (For US Only)
Inventors: LEE, Sun Kyu; (KR).
NAM, Sung Ki; (KR).
JEONG, Su Heon; (KR).
KIM, Jung Kyun; (KR).
WOO, Do Kyun; (KR).
YANG, Sung; (KR)
Agent: WOOIN PATENT & LAW FIRM; (Yeoksam-dong, Jungpyeong Bldg.) 2Fl. 157 Yeoksam-ro, Gangnam-gu Seoul 135-925 (KR)
Priority Data:
10-2010-0043588 10.05.2010 KR
Title (EN) SENSOR FOR MEASURING THE CALORIFIC VALUE OF A CELL USING THE ZWEIFACH-FUNG EFFECT, AND METHOD FOR MANUFACTURING SAME
(FR) CAPTEUR POUR MESURER LE POUVOIR CALORIFIQUE D'UNE CELLULE À L'AIDE DE L'EFFET ZWEIFACH-FUNG ET PROCÉDÉ DE FABRICATION ASSOCIÉ
(KO) 쯔바이파흐-풍 효과를 이용한 세포 발열량 측정 센서 및 이의 제조방법
Abstract: front page image
(EN)The present invention relates to a sensor for measuring the calorific value of a cell, which includes a thermopile manufactured through surface-micromachining technology, and a microfluid channel structure for mixing cells with culture fluid and separating the cells from the culture fluid. As the sensor according to the present invention for measuring the calorific value of a cell uses a micro-mixer to uniformly mix a culture fluid with cells, uses the Zweifach-Fung effect to separate cells from the culture fluid and then amplifies two thermopile signals of measurements taken from the culture microfluid and cell microfluid, respectively, uses the differences in the values thereof for measuring a cell calorific value, and removes the effects of noise generated by changes in the external environment, the fluidic inertia effect from the flow of fluid, i.e. the effect of calorific value reduction by means of the flow of culture fluid, can be minimized. Thus, a sensor for measuring the calorific value of a cell according to the present invention can precisely measure the calorific value of a cell moving within a microfluid channel, and may be used for the diagnosis of diseases such as cancer by using the difference between the calorific value of the measured cell and a standard calorific value of a normal cell.
(FR)La présente invention se rapporte à un capteur pour mesurer le pouvoir calorifique d'une cellule, qui comprend une thermopile fabriquée à l'aide d'une technologie de micro-usinage de surface, et à une structure de canal de microfluide pour mélanger des cellules à un fluide de culture et séparer les cellules du fluide de culture. Étant donné que le capteur selon la présente invention servant à mesurer le pouvoir calorifique d'une cellule utilise un micro-mélangeur pour mélanger uniformément un fluide de culture à des cellules, utilise l'effet Zweifach-Fung pour séparer des cellules du fluide de culture, puis amplifie deux signaux de thermopile de mesures prises du microfluide de culture et du microfluide de cellule, respectivement, utilise les différences entre leurs valeurs pour mesurer un pouvoir calorifique de cellule, et élimine les effets de bruit générés par les changements sur le plan de l'environnement extérieur, il est possible de réduire à un minimum l'inertie de fluide de l'écoulement de fluide, à savoir l'effet de réduction du pouvoir calorifique à l'aide de l'écoulement du fluide de culture. Par conséquent, un capteur de mesure du pouvoir calorifique d'une cellule conformément à la présente invention peut mesurer avec précision le pouvoir calorifique d'une cellule se déplaçant dans un canal de microfluide, et peut être utilisé pour le diagnostic de maladies telles que le cancer à l'aide de la différence entre le pouvoir calorifique de la cellule mesurée et le pouvoir calorifique standard d'une cellule normale.
(KO)본 발명은 표면 마이크로 머시닝(surface micromaching) 기술에 의해 제작된 써모파일과 세포를 배양액과 혼합하고 다시 분리하기 위한 미세유체 흐름 채널 구조물을 포함하는 세포 발열량 측정 센서를 제공한다. 본 발명에 따른 세포 발열량 측정 센서는 마이크로 믹서을 이용하여 배양액과 세포를 균일하게 혼합하고, 쯔바이파흐-풍 효과(Zweifach-Fung effect)를 이용하여 배양액과 세포를 분리한 후 배양액 미세유체와 세포 미세유체 각각에서 측정된 써모파일의 두 신호을 증폭시키고 그 차이 값을 세포의 발열량 측정에 사용하기 때문에 외부 환경의 변화에 의해 발생하는 노이즈의 영향를 제거하고, 유체의 유동에 의한 대류 열소산 효과, 즉 배양액의 유동에 의한 발열량 감소 효과를 최소화할 수 있다. 따라서, 본 발명에 따른 세포 발열량 측정 센서는 미세유체 흐름 채널 내에서 유동하는 세포의 발열량을 정밀하게 측정할 수 있고, 측정된 세포의 발열량과 정상 세포의 표준 발열량 차이를 이용하여 암 등의 질환을 진단하는 데 사용될 수 있다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Korean (KO)
Filing Language: Korean (KO)