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1. (WO2011142514) COMPOSITION CONTAINING PIAS3 AS AN ACTIVE INGREDIENT FOR PREVENTING OR TREATING CANCER OR IMMUNE DISEASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/142514    International Application No.:    PCT/KR2010/007504
Publication Date: 17.11.2011 International Filing Date: 29.10.2010
IPC:
A61K 48/00 (2006.01), A61K 31/7105 (2006.01), A61P 35/00 (2006.01)
Applicants: CATHOLIC UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION [KR/KR]; 505 Banpo-dong, Seocho-gu Seoul 137-701 (KR) (For All Designated States Except US).
CHO, Mi-La [KR/KR]; (KR) (For US Only).
LEE, Seon-Yeong [KR/KR]; (KR) (For US Only).
MOON, Young-Mee [KR/KR]; (KR) (For US Only).
RYU, Jun-Geol [KR/KR]; (KR) (For US Only).
HER, Yang-Mi [KR/KR]; (KR) (For US Only).
OH, Hye-Jwa [KR/KR]; (KR) (For US Only)
Inventors: CHO, Mi-La; (KR).
LEE, Seon-Yeong; (KR).
MOON, Young-Mee; (KR).
RYU, Jun-Geol; (KR).
HER, Yang-Mi; (KR).
OH, Hye-Jwa; (KR)
Agent: WIE, Byoung-Gab; Godeok Building #401 Seochodaero 255, Seocho-gu Seoul 137-885 (KR)
Priority Data:
10-2010-0045058 13.05.2010 KR
Title (EN) COMPOSITION CONTAINING PIAS3 AS AN ACTIVE INGREDIENT FOR PREVENTING OR TREATING CANCER OR IMMUNE DISEASE
(FR) COMPOSITION CONTENANT DU PIAS3 COMME INGRÉDIENT ACTIF POUR LA PRÉVENTION OU LE TRAITEMENT D'UN CANCER OU D'UNE MALADIE IMMUNE
(KO) PIAS3을 유효성분으로 포함하는 암 또는 면역질환의 예방 또는 치료용 조성물
Abstract: front page image
(EN)The present invention relates to a composition containing PIAS3 as an active ingredient for the prevention or treatment of cancer or immune disease. More specifically, the present invention relates to a composition containing the PIAS3 gene or an expression protein thereof as an active ingredient for the prevention or treatment of cancer or immune disease, to an immunosuppressant composition, to a method for reducing or inhibiting undifferentiated T cells into Th17 cells using the PIAS3 gene or an expression protein thereof, and to a method for activating regulatory T cells. The PIAS3 according to the present invention is excellent in inhibiting the differentiation of cytotoxic Th17 cells which produce and secrete inflammatory cytokines and in activating regulatory T cells (Tregs) having characteristics that inhibit the function of abnormally activated immune cells and control inflammatory responses. Thus, the PIAS3 may be useful as a pharmaceutical composition or immunosuppressant which may prevent or treat cancer or immune disease caused by the dysregulation of immune responses.
(FR)La présente invention concerne une composition contenant du PIAS3 comme ingrédient actif pour la prévention ou le traitement d'un cancer ou d'une maladie immune. Plus spécifiquement, la présente invention concerne une composition contenant le gène PIAS3 ou une protéine d'expression de celui-ci comme ingrédient actif pour la prévention ou le traitement d'un cancer ou d'une maladie immune, une composition d'immunosuppression, un procédé pour la réduction ou l'inhibition de cellules T non différenciées en cellules Th17 en utilisant le gène PIAS3 ou une protéine d'expression de celui-ci, et un procédé pour l'activation de cellules T de régulation. Le PIAS3 selon la présente invention est excellent dans l'inhibition de la différenciation de cellules Th17 cytotoxiques qui produisent et secrètent des cytokines inflammatoires et dans l'activation de cellules T régulatrices (Tregs) présentant des caractéristiques qui inhibent la fonction de cellules immunes anormalement activées et qui contrôlent les réponses inflammatoires. Par conséquent, les PIAS3 peuvent être utiles comme composition pharmaceutique ou d'immunosuppression qui peut prévenir ou traiter un cancer ou une maladie immune provoquée par la dérégulation de réponses immunes.
(KO)본 발명은 PIAS3을 유효성분으로 포함하는 암 또는 면역질환의 예방 또는 치료용 조성물에 관한 것으로서, 보다 구체적으로 본 발명은 PIAS3 유전자 또는 상기 유전자의 발현 단백질을 유효성분으로 포함하는 암 또는 면역질환의 예방 또는 치료용 조성물, 면역억제용 조성물, PIAS3 유전자 또는 상기 유전자의 발현 단백질을 이용한 미분화 T 세포의 Th17 세포로의 분화를 감소 또는 억제하는 방법 및 조절 T 세포를 활성화시키는 방법에 관한 것이다. 본 발명에 따른 상기 PIAS3은 염증성 사이토카인을 생성 및 분비하는 세포 독성 Th17 세포의 분화를 억제하는 효과가 우수하고, 비정상적으로 활성화된 면역세포의 기능을 억제하고 염증 반응을 제어하는 특성을 갖는 면역조절 T 세포(Treg)는 활성화 시키는 효과가 우수하므로 면역반응의 조절 이상으로 유발되는 암 또는 면역질환을 예방 또는 치료할 수 있는 약학적 조성물 또는 면역 억제제로 유용하게 사용할 수 있다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Korean (KO)
Filing Language: Korean (KO)