WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2011142461) ANTIBODY FOR DIAGNOSING AMYOTROPHIC LATERAL SCLEROSIS (ALS)
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/142461    International Application No.:    PCT/JP2011/061069
Publication Date: 17.11.2011 International Filing Date: 13.05.2011
IPC:
C07K 16/40 (2006.01), C12N 5/10 (2006.01), C12N 15/02 (2006.01), C40B 30/04 (2006.01), G01N 33/53 (2006.01), C12P 21/08 (2006.01)
Applicants: THE UNIVERSITY OF TOKYO [JP/JP]; 3-1, Hongo 7-chome, Bunkyo-ku, Tokyo 1138654 (JP) (For All Designated States Except US).
ICHIJO, Hidenori [JP/JP]; (JP) (For US Only).
NISHITOH, Hideki [JP/JP]; (JP) (For US Only)
Inventors: ICHIJO, Hidenori; (JP).
NISHITOH, Hideki; (JP)
Agent: ONO, Shinjiro; YUASA AND HARA, Section 206, New Ohtemachi Bldg., 2-1, Ohtemachi 2-chome, Chiyoda-ku, Tokyo 1000004 (JP)
Priority Data:
2010-111375 13.05.2010 JP
Title (EN) ANTIBODY FOR DIAGNOSING AMYOTROPHIC LATERAL SCLEROSIS (ALS)
(FR) ANTICORPS POUR LE DIAGNOSTIC DE LA SCLÉROSE LATÉRALE AMYOTROPHIQUE (SLA)
(JA) 筋萎縮性側索硬化症(ALS)の診断のための抗体
Abstract: front page image
(EN)The issues addressed by this invention are the determination of part of the molecular mechanism behind the pathogenesis of amyotrophic lateral sclerosis (ALS) and the use of said molecular mechanism to investigate ALS risks. Said issues are addressed by the provision of a method for detecting ALS risks by detecting mutant SOD1 protein. Namely, said issues are addressed by the provision of an antibody for detecting mutant SOD1 protein, where said antibody binds to mutant SOD1 protein but not to wild-type (i.e., normal) SOD1 protein.
(FR)Les problèmes abordés par la présente invention sont la détermination d'une partie du mécanisme moléculaire derrière la pathogenèse de la sclérose latérale amyotrophique (SLA) et l'utilisation dudit mécanisme moléculaire pour rechercher des risques de SLA. Lesdits problèmes sont abordés par la fourniture d'une méthode de détection des risques de SLA par la détection d'une protéine SOD1 mutante. A savoir, lesdits problèmes sont abordés par la fourniture d'un anticorps pour la détection d'une protéine SOD1 mutante, ledit anticorps se liant à la protéine SOD1 mutante mais pas à la protéine SOD1 de type sauvage (c'est-à-dire normale).
(JA) 本発明は、筋萎縮性側索硬化症(ALS)の発症の分子機構の一端を解明し、また、解明されたALS発症の分子機構を利用して、ALSのリスクを調べることを課題とする。本発明は、変異型SOD1タンパク質を検出することにより、ALSのリスクを検出する方法を提供することにより、上記課題を解決した。すなわち、変異型SOD1タンパク質を検出するために、本発明においては、野生型(すなわち正常な)SOD1タンパク質は結合しないが、変異型SOD1タンパク質には結合する抗体を提供することにより、上記課題を解決した。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)