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1. WO2011141889 - INJECTABLE OSTEOINDUCTIVE BONE CEMENTS

Publication Number WO/2011/141889
Publication Date 17.11.2011
International Application No. PCT/IB2011/052094
International Filing Date 12.05.2011
IPC
A61L 27/50 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
50Materials characterised by their function or physical properties
A61L 24/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
24Surgical adhesives or cements; Adhesives for colostomy devices
A61L 27/44 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
40Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material
44having a macromolecular matrix
CPC
A61L 2300/44
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
2300Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
40characterised by a specific therapeutic activity or mode of action
44Radioisotopes, radionuclides
A61L 24/0063
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
24Surgical adhesives or cements; Adhesives for colostomy devices
0047Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
0052with an inorganic matrix
0063Phosphorus containing materials, e.g. apatite
A61L 24/0068
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
24Surgical adhesives or cements; Adhesives for colostomy devices
0047Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
0052with an inorganic matrix
0068Inorganic materials not covered by groups A61L24/0057 or A61L24/0063
A61L 2400/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
2400Materials characterised by their function or physical properties
06Flowable or injectable implant compositions
A61L 2430/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
2430Materials or treatment for tissue regeneration
02for reconstruction of bones; weight-bearing implants
A61L 27/425
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for ; grafts or; prostheses or for coating ; grafts or; prostheses
40Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
42having an inorganic matrix
425of phosphorus containing material, e.g. apatite
Applicants
  • POLITECNICO DI TORINO [IT]/[IT] (AllExceptUS)
  • VITALE BROVARONE, Chiara [IT]/[IT] (UsOnly)
  • VERNE', Enrica [IT]/[IT] (UsOnly)
  • BERGUI, Mauro [IT]/[IT] (UsOnly)
  • ONIDA, Barbara [IT]/[IT] (UsOnly)
  • BAINO, Francesco [IT]/[IT] (UsOnly)
  • MIOLA, Marta [IT]/[IT] (UsOnly)
  • FERRARIS, Sara [IT]/[IT] (UsOnly)
  • TALLIA, Francesca [IT]/[IT] (UsOnly)
Inventors
  • VITALE BROVARONE, Chiara
  • VERNE', Enrica
  • BERGUI, Mauro
  • ONIDA, Barbara
  • BAINO, Francesco
  • MIOLA, Marta
  • FERRARIS, Sara
  • TALLIA, Francesca
Agents
  • RAMBELLI, Paolo
Priority Data
TO2010A00040113.05.2010IT
Publication Language English (en)
Filing Language Italian (IT)
Designated States
Title
(EN) INJECTABLE OSTEOINDUCTIVE BONE CEMENTS
(FR) CIMENTS OSSEUX OSTÉOINDUCTIFS INJECTABLES
Abstract
(EN) An injectable composition for bone filling or consolidation, for use in surgery or therapy, characterized in that it comprises a biocompatible powdery material, which is hardenable or cross-linkable and selected from calcium sulphate hemi-hydrate and polymethylmethacrylate, a hardening or cross-linking agent for said material and a porous silica-based powdery material, having a specific surface area higher than 100 m2/g, which comprises a mesoporous bioactive glass, obtainable/achievable by a sol-gel method with the addition of a surfactant as structure-directing agent for pores formation, comprising an oxide mixture containing: SiO2: from 60 to 85% by moles CaO: from 10 to 30% by moles P2O5: from 2 to 10% by moles said composition, when applied to an affected area of a patient, being adapted to form a composite material wherein said hardenable or cross-linkable material constitutes a matrix and said mesoporous bioactive glass constitutes a dispersed phase in said matrix.
(FR) L'invention concerne une composition injectable pour le remplissage ou la consolidation d'os, que l'on utilise en chirurgie ou en thérapie. Ladite composition se caractérise en ce qu'elle comprend un matériau pulvérulent biocompatible, qui est durcissable ou réticulable et choisie parmi le sulfate de calcium semi-hydrate et le polyméthacrylate de méthyle, un agent durcissant ou réticulant pour ledit matériau et un matériau pulvérulent poreux à base de silice présentant une surface spécifique supérieure à 100 m2/g, qui comprend un verre bioactif mésoporeux que l'on peut obtenir/réaliser par un procédé sol-gel avec l'addition d'un tensio-actif comme agent directeur de structure pour la formation de pores, comprenant un mélange d'oxyde contenant: SiO2: de 60 à 85% en mole, CaO: de 10 à 30% en mole, P2O5: de 21 à 10% en mole de ladite composition, appliquée à une zone affectée du patient, étant conçue pour former un matériau composite dans lequel le matériau durcissable ou réticulable constitue une matrice et ledit verre bioactif mésoporeux une phase dispersée dans ladite matrice.
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