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1. (WO2011140676) RHIZOMA GASTRODIAE PLANT EXTRACT USED TO PREVENT AND TREAT ALZHEIMER DISEASE AND VASCULAR DEMENTIA AND MIXED TYPE DISEASES THEREOF AND PREPARATIVE METHOD THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/140676    International Application No.:    PCT/CN2010/000680
Publication Date: 17.11.2011 International Filing Date: 12.05.2010
IPC:
A61K 31/7034 (2006.01), A61K 36/8988 (2006.01), A61K 9/20 (2006.01), A61K 9/06 (2006.01), A61K 9/48 (2006.01), A61P 25/28 (2006.01), C07H 1/08 (2006.01)
Applicants: BEIJING COLLAB PHARMA CO., LTD [CN/CN]; No. 26, Jinyuan Street, Daxing Industrial Development Area Beijing 102600 (CN) (For All Designated States Except US).
WANG, Ke [CN/CN]; (CN) (For US Only).
LIU, Ye [CN/CN]; (CN) (For US Only).
CHEN, Mingxia [CN/CN]; (CN) (For US Only).
SU, Xiaohui [CN/CN]; (CN) (For US Only).
ZHANG, Xiang [CN/CN]; (CN) (For US Only).
LIU, Suyun [CN/CN]; (CN) (For US Only).
ZHAO, Dalong [CN/CN]; (CN) (For US Only)
Inventors: WANG, Ke; (CN).
LIU, Ye; (CN).
CHEN, Mingxia; (CN).
SU, Xiaohui; (CN).
ZHANG, Xiang; (CN).
LIU, Suyun; (CN).
ZHAO, Dalong; (CN)
Agent: CCPIT PATENT AND TRADEMARK LAW OFFICE; 8th Floor, Vantone New World Plaza 2 Fuchengmenwai Street Beijing 100037 (CN)
Priority Data:
Title (EN) RHIZOMA GASTRODIAE PLANT EXTRACT USED TO PREVENT AND TREAT ALZHEIMER DISEASE AND VASCULAR DEMENTIA AND MIXED TYPE DISEASES THEREOF AND PREPARATIVE METHOD THEREOF
(FR) EXTRAIT VÉGÉTAL DE RHIZOMA GASTRODIAE UTILISÉ POUR LA PRÉVENTION ET LE TRAITEMENT DE LA MALADIE D'ALZHEIMER ET DE LA DÉMENCE VASCULAIRE ET DE MALADIES DE TYPE MIXTE DE CELLES-CI ET SON PROCÉDÉ DE PRÉPARATION
(ZH) 用于防治阿尔茨海默病和血管性痴呆及其混合型等疾病的天麻植物提取物及其制备方法
Abstract: front page image
(EN)The present invention discloses use of Rhizoma Gastrodiae plant extract containing parishin derivative in manufacture of medicaments for preventing and treating Alzheimer disease (AD), vascular dementia (VaD) and mixed type diseases thereof. The present invention also discloses the method for extracting and refining plant extract from Rhizoma Gastrodiae (Gastrodia elata Blume), wherein the effective constituent is parishin derivative, especially parishin A, B, C. The plant extract which is extracted by water or alcohol-water and refined and purified by chromatography contains parishin derivative whose content is more than 35%, especially more than 50%. The dosage forms of the present invention preferably include injection, tablets, capsules, soft capsules, oral liquid or drop pills etc.
(FR)La présente invention concerne l'utilisation d'un extrait végétal de Rhizoma Gastrodiae contenant un dérivé de parishine dans la fabrication de médicaments pour la prévention et le traitement de la maladie d'Alzheimer (AD), de la démence vasculaire (VaD) et de maladies de type mixte de celles-ci. La présente invention porte également sur le procédé d'extraction et de raffinage d'un extrait végétal provenant de Rhizoma Gastrodiae (Gastrodia elata Blume), dans lequel le constituant efficace est un dérivé de parishine, notamment la parishine A, B, C. L'extrait végétal qui est extrait par l'eau ou un mélange alcool-eau et raffiné et purifié par chromatographie contient un dérivé de parishine dont la teneur est supérieure à 35 %, notamment supérieure à 50 %. Les formes posologiques de la présente invention comprennent, de préférence, les formes posologiques pour injection, les comprimés, les capsules, les capsules molles, les liquides pour administration orale ou les comprimés linguaux, etc.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)