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Machine translation
1. (WO2011140516) METHODS FOR CONTROL OF FLUX IN METABOLIC PATHWAYS THROUGH ENZYME RELOCATION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/140516    International Application No.:    PCT/US2011/035639
Publication Date: 10.11.2011 International Filing Date: 06.05.2011
IPC:
C12N 1/00 (2006.01), C12N 1/06 (2006.01), C12N 15/52 (2006.01)
Applicants: GREENLIGHT BIOSCIENCES, INC. [US/US]; 200 Boston Avenue Suite 4100 Medford, MA 02155 (US) (For All Designated States Except US).
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY [US/US]; 1705 El Camino Real Palo Alto, CA 94306-1106 (US) (For All Designated States Except US).
SWARTZ, James, R. [US/US]; (US) (For US Only)
Inventors: SWARTZ, James, R.; (US)
Agent: BAKER, C., Hunter; Wolf, Greenfield & Sacks, P.C. 600 Atlantic Avenue Boston, MA 02210-2206 (US)
Priority Data:
61/332,624 07.05.2010 US
Title (EN) METHODS FOR CONTROL OF FLUX IN METABOLIC PATHWAYS THROUGH ENZYME RELOCATION
(FR) MÉTHODES POUR COMMANDER UN FLUX DANS DES VOIES MÉTABOLIQUES VIA LA RELOCALISATION D'UNE ENZYME
Abstract: front page image
(EN)Genetically manipulated cells, lysates of such cells, systems, and methods of use thereof are provided, where one or more enzymes in a pathway of interest are genetically modified to incorporate a peptide sequence that provides for relocation of the protein, e.g., to the periplasm, so as to sequester the enzyme, and where the enzyme controls flux in the pathway of interest.
(FR)L'invention concerne des cellules génétiquement manipulées, des lysats de ces cellules, des systèmes et leurs procédés d'utilisation, une ou plusieurs enzymes dans une voie d'intérêt étant génétiquement modifiées pour incorporer une séquence peptidique qui permet la relocalisation de la protéine, par exemple dans le périplasme de façon à séquestrer l'enzyme, ladite enzyme commandant un flux dans la voie d'intérêt.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)