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1. (WO2011140433) MEASUREMENT AND COMPARISON OF IMMUNE DIVERSITY BY HIGH-THROUGHPUT SEQUENCING
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2011/140433 International Application No.: PCT/US2011/035507
Publication Date: 10.11.2011 International Filing Date: 06.05.2011
IPC:
G01N 33/48 (2006.01) ,C12Q 1/68 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants:
QUAKE, Stephen R. [US/US]; US (UsOnly)
WEINSTEIN, Joshua [US/US]; US (UsOnly)
JIANG, Ning [CN/US]; US (UsOnly)
FISHER, Daniel, S. [US/US]; US (UsOnly)
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY [US/US]; 1705 El Camino Real Palo Alto, California 94306-1106, US (AllExceptUS)
Inventors:
QUAKE, Stephen R.; US
WEINSTEIN, Joshua; US
JIANG, Ning; US
FISHER, Daniel, S.; US
Agent:
SHERWOOD, Pamela J.; Bozicevic, Field & Francis LLP 1900 University Avenue, Suite 200 East Palo Alto, California 94303, US
Priority Data:
61/395,11607.05.2010US
Title (EN) MEASUREMENT AND COMPARISON OF IMMUNE DIVERSITY BY HIGH-THROUGHPUT SEQUENCING
(FR) MESURE ET COMPARAISON DE DIVERSITÉ IMMUNITAIRE PAR SÉQUENÇAGE À HAUT DÉBIT
Abstract:
(EN) A precise measurement of the immunological receptor diversity present in a sample is obtained by sequence analysis. Samples of interest are generally complex, comprising more than 102, 103, 104, 105, 106, 107, 108,109, 1010, 1011, 1012 or more different sequences for a receptor of interest. Immunological receptors of interest include immunoglobulins, T cell antigen receptors, and major histocompatibility receptors. The specific composition of immunological receptor sequence variations in the sample can be recorded and output. The composition is useful for predictive, diagnostic and therapeutic methods relating to the immune capabilities and history of an individual. Such predictions and diagnoses are used to guide clinical decisions.
(FR) L'invention porte sur une mesure précise, de la diversité des récepteurs immunologiques présents dans un échantillon, qui est obtenue par l'analyse de séquences. Les échantillons d'intérêt sont généralement complexes, comprennent plus de 102, 103, 104, 105, 106, 107, 108, 109, 1010, 1011, 1012 ou plus de séquences différentes pour un récepteur d'intérêt. Les récepteurs immunologiques d'intérêt comprennent des immunoglobines, des récepteurs d'antigènes des lymphocytes T et des récepteurs du complexe majeur d'histocompatibilité. La composition spécifique des variations de séquence des récepteurs immunologiques dans l'échantillon peut être enregistrée et émise. La composition est utile pour des méthodes prédictives, de diagnostic et thérapeutiques liées aux capacités et aux antécédents immunitaires d'un individu. De tels prédictions et diagnostics sont utilisés pour orienter des décisions cliniques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)