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Machine translation
1. (WO2011140425) HETEROCYCLIC CHROMENE-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/140425    International Application No.:    PCT/US2011/035493
Publication Date: 10.11.2011 International Filing Date: 06.05.2011
IPC:
C07D 491/20 (2006.01), C07D 498/20 (2006.01), A61K 31/438 (2006.01), A61P 25/04 (2006.01)
Applicants: VERTEX PHARMACEUTICALS INCORPORATED [US/US]; 130 Waverly Street Cambridge, MA 02319 (US) (For All Designated States Except US).
HADIDA-RUAH, Sara, Sabina [US/US]; (US) (For US Only).
KALLEL, Edward, Adam [US/US]; (US) (For US Only).
MILLER, Mark, Thomas [US/US]; (US) (For US Only).
PONTILLO, Joseph [CA/US]; (US) (For US Only).
ANDERSON, Corey [US/US]; (US) (For US Only).
NUMA, Mehdi [FR/US]; (US) (For US Only).
FRIEMAN, Bryan, A. [US/US]; (US) (For US Only).
BEAR, Brian, Richard [US/US]; (US) (For US Only).
ARUMUGAM, Vijayalaksmi [US/US]; (US) (For US Only).
HILGRAF, Nicole [DE/US]; (US) (For US Only).
MCCARTNEY, Jason [US/US]; (US) (For US Only).
GROOTENHUIS, Peter, Diederik Jan [NL/US]; (US) (For US Only).
JOHNSON, James, Philip [US/US]; (US) (For US Only)
Inventors: HADIDA-RUAH, Sara, Sabina; (US).
KALLEL, Edward, Adam; (US).
MILLER, Mark, Thomas; (US).
PONTILLO, Joseph; (US).
ANDERSON, Corey; (US).
NUMA, Mehdi; (US).
FRIEMAN, Bryan, A.; (US).
BEAR, Brian, Richard; (US).
ARUMUGAM, Vijayalaksmi; (US).
HILGRAF, Nicole; (US).
MCCARTNEY, Jason; (US).
GROOTENHUIS, Peter, Diederik Jan; (US).
JOHNSON, James, Philip; (US)
Agent: DIVERDI, Michael, J.; VERTEX PHARMACEUTICALS INCORPORATED 130 Waverly Street Cambridge, MA 02139 (US)
Priority Data:
61/331,882 06.05.2010 US
61/438,688 02.02.2011 US
Title (EN) HETEROCYCLIC CHROMENE-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS
(FR) AMIDES DE CHROMÈNE HÉTÉROCYCLIQUE-PIPÉRIDINE SPIROCYCLIQUE UTILES COMME MODULATEURS DES CANAUX IONIQUES
Abstract: front page image
(EN)The invention relates to heterocyclic chromene-spirocyclic piperidine amides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
(FR)La présente invention concerne des amides de chromène hétérocyclique-pipéridine spirocyclique pouvant être employés en tant qu'inhibiteurs de canaux ioniques. La présente invention concerne également des compositions de qualité pharmaceutique comprenant lesdits composés, et des méthodes d'emploi desdites compositions dans le traitement de divers troubles.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)