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Machine translation
1. (WO2011140333) IDENTIFICATION OF STABILIZERS OF MULTIMERIC PROTEINS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/140333    International Application No.:    PCT/US2011/035350
Publication Date: 10.11.2011 International Filing Date: 05.05.2011
IPC:
A01N 43/78 (2006.01), A61K 31/425 (2006.01)
Applicants: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY [US/US]; 1705 El Camino Real Palo Alto, California 94306-1106 (US) (For All Designated States Except US).
GRAEF, Isabella A. [AT/US]; (US) (For US Only).
ALHAMADSHEH, Mamoun [JO/US]; (US) (For US Only)
Inventors: GRAEF, Isabella A.; (US).
ALHAMADSHEH, Mamoun; (US)
Agent: BABA, Edward J.; BOZICEVIC, FIELD & FRANCIS LLP 1900 University Avenue, Suite 200 East Palo Alto, California 94303 (US)
Priority Data:
61/332,638 07.05.2010 US
Title (EN) IDENTIFICATION OF STABILIZERS OF MULTIMERIC PROTEINS
(FR) IDENTIFICATION DE STABILISANTS DE PROTÉINES MULTIMÉRIQUES
Abstract: front page image
(EN)Disclosed herein are compounds and compositions thereof which find use in increasing stability of TTR tetramers reducing its tendency to misfold and form aggregates. Also provided herein are methods for using these compounds and compositions for increasing stability of TTR and therby decreasing aggegate formation by TTR. Also disclosed herein are methods to screen for candidate compounds that increase stability of TTR. Also disclosed herein are heterobifunctional compounds that include a TTR binding compound connected to a targeting moiety via a linker, for use in disrupting PPIs of a target protein.
(FR)La présente invention concerne des composés et des compositions de ceux-ci permettant d'accroître la stabilité des tétramères TTR en réduisant sa tendance à un mauvais repliement et à la formation d'agrégats. L'invention concerne également des procédés d'utilisation de ces composés et compositions pour accroître la stabilité du TTR et donc de réduire la formation d'agrégats par le TTR. L'invention concerne en outre des procédés pour le criblage de composés candidats qui accroissent la stabilité de TTR. L'invention concerne enfin des composés hétérobifonctionnels qui comprennent un composé de liaison au TTR relié à une fraction de ciblage via un lieur, destinés à être utilisés dans la disruption d'inhibition des pré-impulsions (PPI) d'une protéine cible.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)