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1. (WO2011140296) TRIAZOLES AS INHIBITORS OF FATTY ACID SYNTHASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/140296    International Application No.:    PCT/US2011/035291
Publication Date: 10.11.2011 International Filing Date: 05.05.2011
IPC:
C07D 249/04 (2006.01), C07D 249/06 (2006.01), C07D 249/18 (2006.01), C07D 401/06 (2006.01), C07D 471/00 (2006.01), A61K 31/4192 (2006.01), A61P 31/00 (2006.01)
Applicants: INFINITY PHARMACEUTICALS, INC. [US/US]; 780 Memorial Drive Cambridge, MA 02139 (US) (For All Designated States Except US).
BAHADOOR, Adilah [MU/US]; (US) (For US Only).
CASTRO, Alfredo, C. [US/US]; (US) (For US Only).
CHAN, Lawrence, K. [CN/US]; (US) (For US Only).
KEANEY, Gregg, F. [US/US]; (US) (For US Only).
NEVALAINEN, Marta [FR/US]; (US) (For US Only).
NEVALAINEN, Vesa [US/US]; (US) (For US Only).
PELUSO, Stephane [FR/US]; (US) (For US Only).
TIBBITTS, Thomas, T. [US/US]; (US) (For US Only)
Inventors: BAHADOOR, Adilah; (US).
CASTRO, Alfredo, C.; (US).
CHAN, Lawrence, K.; (US).
KEANEY, Gregg, F.; (US).
NEVALAINEN, Marta; (US).
NEVALAINEN, Vesa; (US).
PELUSO, Stephane; (US).
TIBBITTS, Thomas, T.; (US)
Agent: INSOGNA, Anthony, M.; Jones Day 222 East 41st Street New York, NY 10017-6702 (US)
Priority Data:
61/331,632 05.05.2010 US
Title (EN) TRIAZOLES AS INHIBITORS OF FATTY ACID SYNTHASE
(FR) TRIAZOLES UTILISÉS COMME INHIBITEURS D'ACIDES GRAS SYNTHASE (FASN)
Abstract: front page image
(EN)Provided herein are triazole FASN inhibitors of the formula (I): (I) or a pharmaceutically acceptable form thereof; wherein the variables RA, X, RB, and RC are defined herein. Also provided herein are pharmaceutical compositions of the compounds provided herein as well as methods of their use for the treatment of various disorders such as hyperproliferative disorders, inflammatory disorders, obesity-related disorders and microbial infections.
(FR)L'invention concerne des inhibiteurs triazoles de FASN représentés par la formule (I) ou une forme de ceux-ci pharmaceutiquement acceptables. Dans la formule (I), les variables RA, X, RB et RC sont telles que définies dans la spécification. L'invention concerne également des compositions pharmaceutiques des composés précités ainsi que leurs procédés d'utilisation pour traiter des troubles variés, tels que les troubles hyper-prolifératifs, les troubles inflammatoires, les troubles liés à l'obésité et les infections microbiennes.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)