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Machine translation
1. (WO2011140295) MODULATORS OF NOTCH RECEPTOR SIGNALING AND METHODS OF USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/140295    International Application No.:    PCT/US2011/035290
Publication Date: 10.11.2011 International Filing Date: 05.05.2011
IPC:
C07K 16/18 (2006.01), A61K 39/395 (2006.01), A61P 35/00 (2006.01), A61P 37/00 (2006.01)
Applicants: PRESIDENT AND FELLOWS OF HARVARD COLLEGE [US/US]; 17 Quincy Street Cambridge, MA 02138 (US) (For All Designated States Except US).
ARTAVANIS-TSAKONAS, Spyros [US/US]; (US) (For US Only).
WALZ, Thomas [CH/US]; (US) (For US Only).
KELLY, Deborah, F. [US/US]; (US) (For US Only).
LAKE, Robert, John [US/US]; (US) (For US Only)
Inventors: ARTAVANIS-TSAKONAS, Spyros; (US).
WALZ, Thomas; (US).
KELLY, Deborah, F.; (US).
LAKE, Robert, John; (US)
Agent: LACCOTRIPE ZACHARAKIS, Maria; Mccarter & English, LLP 265 Franklin Street, 14th Floor Boston, MA 02110 (US)
Priority Data:
61/332,089 06.05.2010 US
Title (EN) MODULATORS OF NOTCH RECEPTOR SIGNALING AND METHODS OF USE THEREOF
(FR) MODULATEURS DE LA SIGNALISATION DU RÉCEPTEUR NOTCH ET LEURS PROCÉDÉS D'UTILISATION
Abstract: front page image
(EN)The present invention provides moieties that bind to the ectodomain of a NOCTH receptor and modulate cleavage and/or NOTCH signaling. The present invention also provides methods of treating or preventing a NOTCH- associated disease and methods for identifying moieties that bind to one or more EGF-like repeats of a NOTCH receptor.
(FR)La présente invention concerne des fragments qui se lient à l'ectodomaine d'un récepteur NOTCH et modulent le clivage et/ou la signalisation NOTCH. La présente invention concerne également des méthodes de traitement ou de prévention d'une maladie associée à NOTCH et des méthodes d'identification des fragments qui se lient à une ou plusieurs répétitions de type EGF d'un récepteur NOTCH.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)