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1. (WO2011140190) TETRAZOLONES AS INHIBITORS OF FATTY ACID SYNTHASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/140190    International Application No.:    PCT/US2011/035141
Publication Date: 10.11.2011 International Filing Date: 04.05.2011
IPC:
C07D 257/04 (2006.01), C07D 401/06 (2006.01), C07D 401/12 (2006.01), C07D 403/06 (2006.01), C07D 403/12 (2006.01), C07D 407/12 (2006.01), C07D 413/06 (2006.01), C07D 413/12 (2006.01), C07D 417/04 (2006.01), C07D 417/06 (2006.01), A61K 31/41 (2006.01), A61P 3/00 (2006.01), A61P 29/00 (2006.01), A61P 35/00 (2006.01)
Applicants: INFINITY PHARMACEUTICALS [US/US]; 780 Memorial Drive Cambridge, MA 02139 (US) (For All Designated States Except US).
BAHADOOR, Adilah [MU/US]; (US) (For US Only).
CASTRO, Alfredo, C. [US/US]; (US) (For US Only).
CHAN, Lawrence, K. [--/US]; (US) (For US Only).
KEANEY, Gregg, F. [US/US]; (US) (For US Only).
NEVALAINEN, Marta [US/US]; (US) (For US Only).
NEVALAINEN, Vesa [US/US]; (US) (For US Only).
PELUSO, Stephane [FR/US]; (US) (For US Only).
SNYDER, Daniel, A. [US/US]; (US) (For US Only).
TIBBITTS, Thomas, T. [US/US]; (US) (For US Only)
Inventors: BAHADOOR, Adilah; (US).
CASTRO, Alfredo, C.; (US).
CHAN, Lawrence, K.; (US).
KEANEY, Gregg, F.; (US).
NEVALAINEN, Marta; (US).
NEVALAINEN, Vesa; (US).
PELUSO, Stephane; (US).
SNYDER, Daniel, A.; (US).
TIBBITTS, Thomas, T.; (US)
Agent: INSOGNA, Anthony, M.; JONES DAY 222 East 41st Street New York, NY 10017-6702 (US)
Priority Data:
61/331,575 05.05.2010 US
61/331,644 05.05.2010 US
61/437,564 28.01.2011 US
61/472,566 06.04.2011 US
61/419,174 02.12.2010 US
Title (EN) TETRAZOLONES AS INHIBITORS OF FATTY ACID SYNTHASE
(FR) TÉTRAZOLONES UTILISÉS EN TANT QU'INHIBITEURS D'ACIDE GRAS SYNTHASE (FASN)
Abstract: front page image
(EN)Provided herein are tetrazolone FASN inhibitors of the formula (I): (I) or a pharmaceutically acceptable form thereof; wherein the variables RA, RB and RC are defined herein. Also provided herein are pharmaceutical compositions of the compounds provided herein as well as methods of their use for the treatment of various disorders such as hyperproliferative disorders, inflammatory disorders, obesity-related disorders and microbial infections.
(FR)L'invention concerne des inhibiteurs de de FASN de la famille des tétrazolones représentés par la formule (I): (I) ou une forme pharmaceutiquement acceptable de ceux-ci; les variables RA, RB et RC étant définies dans la spécification. L'invention concerne également des compositions pharmaceutiques des composés précités ainsi que des méthodes permettant de les utiliser pour traiter divers troubles, tels que des troubles hyperprolifératifs, des troubles inflammatoires, des troubles associés à l'obésité et des infections microbiennes.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)