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1. (WO2011140088) INCREASING BACTERIAL SUCCINATE PRODUCTIVITY INCREASING BACTERIAL SUCCINATE PRODUCTIVITY INCREASING BACTERIAL SUCCINATE PRODUCTIVITY INCREASING BACTERIAL SUCCINATE PRODUCTIVITY INCREASING BACTERIAL SUCCINATE PRODUCTIVITY INCREASING BACTERIAL SUCCINATE PRODUCTIVITY INCREASING BACTERIAL SUCCINATE PRODUCTIVITY INCREASING BACTERIAL SUCCINATE PRODUCTIVITY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/140088    International Application No.:    PCT/US2011/035001
Publication Date: 10.11.2011 International Filing Date: 03.05.2011
IPC:
C12P 7/62 (2006.01), C12N 1/20 (2006.01)
Applicants: WILLIAM MARSH RICE UNIVERSITY [US/US]; Office Of Technology Transfer, Ms 705 6100 Main Street Houston, TX 77005 (US) (For All Designated States Except US).
SAN, Ka-yiu [US/US]; (US) (For US Only).
BENNETT, George [US/US]; (US) (For US Only).
BALZER, Grant [US/US]; (US) (For US Only).
ZHU, Jiangfeng [CN/US]; (US) (For US Only).
THAKKER, Chandresh [IN/US]; (US) (For US Only).
SANCHEZ, Ailen [DO/US]; (US) (For US Only)
Inventors: SAN, Ka-yiu; (US).
BENNETT, George; (US).
BALZER, Grant; (US).
ZHU, Jiangfeng; (US).
THAKKER, Chandresh; (US).
SANCHEZ, Ailen; (US)
Agent: VALOIR, Tamsen; Boulware & Valoir 3 Riverway, Suite 950 Houston, TX 77056 (US)
Priority Data:
61/332,427 07.05.2010 US
Title (EN) INCREASING BACTERIAL SUCCINATE PRODUCTIVITY INCREASING BACTERIAL SUCCINATE PRODUCTIVITY INCREASING BACTERIAL SUCCINATE PRODUCTIVITY INCREASING BACTERIAL SUCCINATE PRODUCTIVITY INCREASING BACTERIAL SUCCINATE PRODUCTIVITY INCREASING BACTERIAL SUCCINATE PRODUCTIVITY INCREASING BACTERIAL SUCCINATE PRODUCTIVITY INCREASING BACTERIAL SUCCINATE PRODUCTIVITY
(FR) AUGMENTATION DE LA PRODUCTIVITÉ EN SUCCINATE DE BACTÉRIES
Abstract: front page image
(EN)Improved bacteria for making succinate and other (4) carbon dicarboxylates from the Krebs cycle have modifications to reduce acetate, lactate, EtOH and formate, as well as turn on the glyoxylate shunt, produce more NADH and overexpress PYC. In one embodiment, the bacteria are ΔadhEΔldhAΔiclRΔack-pta plus PYC+ and NAD+-dependant FDH+. Improved bacteria for making succinate and other (4) carbon dicarboxylates from the Krebs cycle have modifications to reduce acetate, lactate, EtOH and formate, as well as turn on the glyoxylate shunt, produce more NADH and overexpress PYC. In one embodiment, the bacteria are ΔadhEΔldhAΔiclRΔack-pta plus PYC+ and NAD+-dependant FDH+.Improved bacteria for making succinate and other (4) carbon dicarboxylates from the Krebs cycle have modifications to reduce acetate, lactate, EtOH and formate, as well as turn on the glyoxylate shunt, produce more NADH and overexpress PYC. In one embodiment, the bacteria are ΔadhEΔldhAΔiclRΔack-pta plus PYC+ and NAD+-dependant FDH+.
(FR)La présente invention concerne des bactéries améliorées capables de produire du succinate et d'autres dicarboxylates de carbone (4) dans le cadre du cycle de Krebs, bactéries qui ont été modifiées en vue d'une réduction de leur production d'acétate, de lactate, d'EtOH et de formiate, ainsi que pour activer le cycle du glyoxylate, produire davantage de NADH et sur-exprimer PYC. Dans un mode de réalisation, lesdites bactéries sont PYC+ ΔadhEΔldhAΔiclRΔack-pta plus et FDH+ NAD+-dépendantes.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)