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Pub. No.:    WO/2011/139897    International Application No.:    PCT/US2011/034584
Publication Date: 10.11.2011 International Filing Date: 29.04.2011
C07D 311/74 (2006.01), A61K 31/335 (2006.01), A61P 39/06 (2006.01)
Applicants: UNIVERSITY OF MASSACHUSETTS [US/US]; 225 Franklin Street, 12th Floor Boston, MA 02110 (US) (For All Designated States Except US).
RYAN, David, K. [US/US]; (US) (For US Only).
BAYALA, Isso [BF/US]; (US) (For US Only).
ROGERS, Eugene [US/US]; (US) (For US Only)
Inventors: RYAN, David, K.; (US).
BAYALA, Isso; (US).
ROGERS, Eugene; (US)
Agent: PIERCE, N., Scott; Hamilton, Brook, Smith & Reynolds, P.C. 530 Virginia Rd, P.O. Box 9133 Concord, MA 01742-9133 (US)
Priority Data:
61/329,555 29.04.2010 US
Abstract: front page image
(EN)α-tocopherol quinone is chemically reduced by combination with a reducing agent, such as tin (II) ion in the form of stannous chloride (SnCl2-2H20), or by chromium (III) ion, such as chromium (III) in the form of chromium chloride (CrCl3- 6H20). Purified α-tocopherol is obtained from α-tocopherol formed by reduction of an oxidized α-tocopherol, such as α-tocopherol quinone, by tin (II) ion or chromium (III) ion. Purified a-tocopherol of the invention can be administered to patients in need thereof, α-tocopherol is preserved by combination with a reducing agent.
(FR)L'α-tocophérol quinone est réduite de manière chimique par combinaison avec un agent réducteur, tel qu'un ion d'étain (II) sous la forme de chlorure stanneux (SnCl2-2H2O), ou un ion chrome (III), tel que du chrome (III) sous la forme de chlorure de chrome (CrCl3- 6H20). L'α-tocophérol purifié est obtenu à partir d'α-tocophérol formé par réduction d'un α-tocophérol oxydé, tel que l'α-tocophérol quinone, par le biais d'un ion d'étain (II) ou d'un ion de chrome (III). L'α-tocophérol purifié selon la présente invention peut être administré à des patients qui en ont besoin, l'α-tocophérol étant conservé par combinaison avec un agent réducteur.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)