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1. (WO2011139846) COMPOSITIONS AND METHODS FOR REDUCED SCARRING AND FOR TREATMENT OF FIBROSIS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/139846    International Application No.:    PCT/US2011/034357
Publication Date: 10.11.2011 International Filing Date: 28.04.2011
IPC:
C12N 15/113 (2010.01), A61K 31/7088 (2006.01), A61K 39/395 (2006.01)
Applicants: KATHJU, Sandeep [US/US]; (US).
SATISH, Latha [US/US]; (US) (For US Only)
Inventors: KATHJU, Sandeep; (US)
Agent: FRIEDMAN, Barry, I.; Metz Lewis Brodman Must O'Keefe LLC 11 Stanwix Street, 18th Floor Pittsburgh, Pennsylvania 15222 (US)
Priority Data:
61/328,957 28.04.2010 US
Title (EN) COMPOSITIONS AND METHODS FOR REDUCED SCARRING AND FOR TREATMENT OF FIBROSIS
(FR) COMPOSITIONS ET MÉTHODES POUR RÉDUIRE LES CICATRICES ET TRAITER LA FIBROSE
Abstract: front page image
(EN)Methods of treating, reducing or preventing fibrosis or scarring including administering a therapeutic molecular agent selected from the group consisting of an agent that inhibits chaperonin containing Tcomplex polypeptide subunit eta polypeptide ("CCT -eta"), an agent that inhibits a-Smooth Muscle Actin ("a-SMA"), or a combination thereof, are presented. The fibrosis may include Dupuytren's contracture, Peyronie's disease, pulmonary fibrosis, cirrhosis, interstitial lung disease or scarring alopecia.
(FR)Les modes de réalisation de la présente invention concernent des méthodes destinées à traiter, à réduire ou à prévenir la fibrose ou la formation de cicatrices, lesdites méthodes comprenant l'administration d'un agent moléculaire thérapeutique choisi dans le groupe constitué par un agent qui inhibe le polypeptide à sous-unités eta du complexe du récepteur des cellules T contenant la chaperonine ( » CCT-eta »), un agent qui inhibe l'α-actine des muscles lisses ( »α-SMA »), ou leur combinaison. Dans certains modes de réalisation, la fibrose peut comprendre la contracture de Dupuytren, la maladie de Peyronie, la fibrose pulmonaire, la cirrhose, la pneumopathie interstitielle ou l'alopécie de cicatrisation.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)