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1. (WO2011139710) NUCLEIC ACID COMPOUNDS WITH CONFORMATIONALLY RESTRICTED MONOMERS AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/139710    International Application No.:    PCT/US2011/033980
Publication Date: 10.11.2011 International Filing Date: 26.04.2011
IPC:
C12N 15/113 (2010.01), A61P 35/00 (2006.01)
Applicants: MARINA BIOTECH, INC. [US/US]; Marina Biotech, Inc. 3830 Monte Villa Parkway Bothell, WA 98021 (US) (For All Designated States Except US).
VAISH, Narendra, K. [US/US]; (US) (For US Only).
FOSNAUGH, Kathy, L. [US/US]; (US) (For US Only).
SETH, Shaguna [IN/US]; (US) (For US Only).
HOUSTON JR., Michael, E. [CA/US]; (US) (For US Only).
TEMPLIN, Michael, V. [US/US]; (US) (For US Only)
Inventors: VAISH, Narendra, K.; (US).
FOSNAUGH, Kathy, L.; (US).
SETH, Shaguna; (US).
HOUSTON JR., Michael, E.; (US).
TEMPLIN, Michael, V.; (US)
Agent: ECKMAN, Richard R.; Eckman Basu LLP 2225 East Bayshore Road, Suite 200 Palo Alto, CA 94303-3220 (US)
Priority Data:
61/328,140 26.04.2010 US
61/467,048 24.03.2011 US
Title (EN) NUCLEIC ACID COMPOUNDS WITH CONFORMATIONALLY RESTRICTED MONOMERS AND USES THEREOF
(FR) COMPOSÉS D'ACIDE NUCLÉIQUE AYANT DES MONOMÈRES À CONFORMATION RESTREINTE ET LEURS UTILISATIONS
Abstract: front page image
(EN)This disclosure provides single-stranded and multi-stranded nucleic acid compounds having one or more double-stranded regions that regulate the function or expression of nucleic acid molecules expressed in a cell or a cell regulatory system dependent upon a nucleic acid. The disclosure provides a range of nucleic acid compounds having one or more conformationally restricted nucleomonomers (CRN). Certain nucleic acid compounds may have one or more conformationally restricted nucleomonomers and one or more hydroxymethyl substituted nucleomonomers (UNA). The nucleic acid compounds are useful in various therapeutic modalities.
(FR)Cette invention porte sur des composés d'acide nucléique à simple brin et à brins multiples ayant une ou plusieurs régions à double brin qui régulent la fonction ou l'expression de molécules d'acide nucléique exprimées dans une cellule, ou sur un système de régulation cellulaire dépendant d'un acide nucléique. L'invention porte sur une gamme de composés d'acide nucléique ayant un ou plusieurs nucléomonomères à conformation restreinte (CRN). Certains composés d'acide nucléique peuvent avoir un ou plusieurs nucléomonomères à conformation restreinte et un ou plusieurs nucléomonomères substitués par hydroxyméthyle (UNA). Les composés d'acide nucléique sont utiles dans diverses modalités thérapeutiques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)