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1. (WO2011139387) TREATMENT OF SIRTUIN (SIRT) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO A SIRTUIN (SIRT)
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/139387    International Application No.:    PCT/US2011/021052
Publication Date: 10.11.2011 International Filing Date: 13.01.2011
IPC:
C12N 15/113 (2010.01), A61K 31/7088 (2006.01), A61K 48/00 (2006.01), A61P 17/00 (2006.01)
Applicants: CuRNA, Inc. [US/US]; 4400 Biscayne Boulevard Miami, FL 33137 (US) (For All Designated States Except US).
COLLARD, Joseph [US/US]; (US) (For US Only).
KHORKOVA SHERMAN, Olga [US/US]; (US) (For US Only).
COITO, Carlos [PT/US]; (US) (For US Only).
DE LEON, Belinda [US/US]; (US) (For US Only)
Inventors: COLLARD, Joseph; (US).
KHORKOVA SHERMAN, Olga; (US).
COITO, Carlos; (US).
DE LEON, Belinda; (US)
Agent: BROWDER, Monte, R.; OPKO CuRNA, LLC 4400 Biscayne Boulevard Miami, FL 33137 (US)
Priority Data:
61/330,427 03.05.2010 US
61/409,136 02.11.2010 US
61/412,066 10.11.2010 US
61/415,891 22.11.2010 US
Title (EN) TREATMENT OF SIRTUIN (SIRT) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO A SIRTUIN (SIRT)
(FR) TRAITEMENT DE MALADIES LIÉES À UNE SIRTUINE (SIRT) PAR INHIBITION DE LA TRANSCRIPTION ANTISENS NATURELLE POUR DONNER UNE SIRTUINE (SIRT)
Abstract: front page image
(EN)The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of a Sirtuin (SIRT), in particular, by targeting natural antisense polynucleotides of a Sirtuin (SIRT). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of Sirtuins (SIRT)s.
(FR)La présente invention concerne des oligonucléotides antisens qui modulent l'expression et/ou la fonction d'une sirtuine (SIRT), notamment en ciblant des polynucléotides antisens naturels d'une sirtuine (SIRT). L'invention a également pour objet l'identification de ces oligonucléotides antisens et leur utilisation pour traiter des maladies et des troubles associés à l'expression de sirtuines (SIRT).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)