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1. (WO2011139132) METHOD FOR THE MASS PROLIFERATION OF EMBRYOID BODIES PRODUCED FROM STEM CELLS, AND FOR MAINTAINING THE EMBRYOID BODIES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/139132    International Application No.:    PCT/KR2011/003439
Publication Date: 10.11.2011 International Filing Date: 09.05.2011
IPC:
C12N 5/0735 (2010.01)
Applicants: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY [KR/KR]; 52, Eoeun-dong, Yuseong-gu Daejeon 305-806 (KR) (For All Designated States Except US).
CHO, Yee Sook [KR/KR]; (KR) (For US Only).
SON, Mi Young [KR/KR]; (KR) (For US Only).
KIM, Hyun Jin [KR/KR]; (KR) (For US Only)
Inventors: CHO, Yee Sook; (KR).
SON, Mi Young; (KR).
KIM, Hyun Jin; (KR)
Agent: SON, Min; HANOL Intellectual Property & Law 6th Floor, City Air Tower 159-9 Samseong-dong, Gangnam-gu Seoul 135-973 (KR)
Priority Data:
10-2010-0043211 07.05.2010 KR
Title (EN) METHOD FOR THE MASS PROLIFERATION OF EMBRYOID BODIES PRODUCED FROM STEM CELLS, AND FOR MAINTAINING THE EMBRYOID BODIES
(FR) PROCÉDÉ DE MULTIPLICATION EN GRAND NOMBRE DE CORPS EMBRYOÏDES À PARTIR DE CELLULES SOUCHES, AINSI QUE D'ENTRETIEN DESDITS CORPS EMBRYOÏDES
(KO) 줄기세포로부터 생성된 배아체를 대량 증식 및 유지하는 방법
Abstract: front page image
(EN)The present invention relates to a method for the mass proliferation of embryoid bodies produced from stem cells, and for maintaining the embryoid bodies. More particularly, the present invention relates to a method for the mass proliferation of embryoid bodies and for maintaining the embryoid bodies, which involves culturing embryoid bodies over a long period of time and maintaining the original properties of the embryoid bodies, wherein the method comprises a step of continuously subculturing embryoid bodies primarily produced from embryonic stem cells or from induced pluripotent stem cells. According to the method of the present invention, it is possible to mass-produce and maintain embryoid boides by a technically simple mechanical subculturing, without the continuous consumption of stem cells, after the embryoid bodies are produced from a limited amount of stem cell fraction.
(FR)La présente invention concerne un procédé de multiplication en grand nombre de corps embryoïdes à partir de cellules souches, ainsi que d'entretien desdits corps embryoïdes. La présente invention concerne, plus précisément, un procédé de multiplication en grand nombre de corps embryoïdes et d'entretien desdits corps embryoïdes, impliquant la culture de corps embryoïdes sur une longue durée et la conservation des propriétés d'origine des corps embryoïdes, ledit procédé comprenant une étape consistant à repiquer en continu des corps embryoïdes initialement obtenus à partir de cellules souches embryonnaires ou de cellules souches pluripotentes induites. Selon le procédé de la présente invention, il est possible de produire en grand nombre et d'entretenir des corps embryoïdes par un repiquage mécanique techniquement simple et sans consommation continue de cellules souches, après production desdits corps embryoïdes à partir d'une quantité limitée de cellules souches.
(KO)본 발명은 줄기세포로부터 생성된 배아체를 대량 증식 및 유지하는 방법에 관한 것으로, 구체적으로 배아줄기세포 또는 유도 만능줄기세포로부터 일차적으로 제작된 배아체를 연속적으로 계대 배양하는 단계를 포함하는, 배아체를 장시간 배양하면서 본래의 성질을 유지한 채 대량 증식 및 유지하는 방법에 관한 것이다. 본 발명의 방법을 이용하면 제한된 양의 줄기세포 분획으로부터 배아체를 제작한 후, 지속적으로 줄기세포를 소모하지 않고도 기술적으로 단순한 기계적 계대 배양 방법을 이용하여 배아체를 대량 생산 및 유지하는 것이 가능하다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Korean (KO)
Filing Language: Korean (KO)