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1. (WO2011139107) PICOLINAMIDE AND PYRIMIDINE-4-CARBOXAMIDE COMPOUNDS, PROCESS FOR PREPARING AND PHAMACEUTICAL COMPOSITION COMPRISING THE SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/139107    International Application No.:    PCT/KR2011/003362
Publication Date: 10.11.2011 International Filing Date: 04.05.2011
IPC:
C07D 401/04 (2006.01), C07D 401/14 (2006.01), C07D 413/14 (2006.01), A61K 31/444 (2006.01), A61K 31/496 (2006.01), A61P 3/10 (2006.01), A61P 3/06 (2006.01)
Applicants: SK Chemicals Co.,Ltd. [KR/KR]; 600, Jeongja-dong, Jangan-gu, Suwon-si, Gyeonggi-do 440-300 (KR) (For All Designated States Except US).
RYU, Je Ho [KR/KR]; (KR) (For US Only).
KIM, Shin Ae [KR/KR]; (KR) (For US Only).
RYU, Keun Ho [KR/KR]; (KR) (For US Only).
KIM, Jae Sun [KR/KR]; (KR) (For US Only).
KIM, Nam Ho [KR/KR]; (KR) (For US Only).
HAN, Hye Young [KR/KR]; (KR) (For US Only).
KIM, Yong Hyuk [KR/KR]; (KR) (For US Only).
YOUN, Won-No [KR/KR]; (KR) (For US Only).
LEE, Yoon-Jung [KR/KR]; (KR) (For US Only).
SON, Hyun Joo [KR/KR]; (KR) (For US Only).
LEE, Bong-yong [KR/KR]; (KR) (For US Only).
PARK, Sung Hoon [KR/KR]; (KR) (For US Only).
LEE, Ju Young [KR/KR]; (KR) (For US Only).
LEE, Hyun Jung [KR/KR]; (KR) (For US Only).
JUNG, Hoe Chul [KR/KR]; (KR) (For US Only).
SHIN, Young Ah [KR/KR]; (KR) (For US Only).
LEE, Jung A [KR/KR]; (KR) (For US Only).
LEE, Bo Ram [KR/KR]; (KR) (For US Only).
SA, Joon Ho [KR/KR]; (KR) (For US Only)
Inventors: RYU, Je Ho; (KR).
KIM, Shin Ae; (KR).
RYU, Keun Ho; (KR).
KIM, Jae Sun; (KR).
KIM, Nam Ho; (KR).
HAN, Hye Young; (KR).
KIM, Yong Hyuk; (KR).
YOUN, Won-No; (KR).
LEE, Yoon-Jung; (KR).
SON, Hyun Joo; (KR).
LEE, Bong-yong; (KR).
PARK, Sung Hoon; (KR).
LEE, Ju Young; (KR).
LEE, Hyun Jung; (KR).
JUNG, Hoe Chul; (KR).
SHIN, Young Ah; (KR).
LEE, Jung A; (KR).
LEE, Bo Ram; (KR).
SA, Joon Ho; (KR)
Agent: KWON, Oh-Sig; 4F, Jooeunleaderstel, 921, Dunsan-dong, Seo-gu Daejeon 302-120 (KR)
Priority Data:
10-2010-0043168 07.05.2010 KR
10-2011-0037758 22.04.2011 KR
Title (EN) PICOLINAMIDE AND PYRIMIDINE-4-CARBOXAMIDE COMPOUNDS, PROCESS FOR PREPARING AND PHAMACEUTICAL COMPOSITION COMPRISING THE SAME
(FR) COMPOSÉS DE PICOLINAMIDE ET DE PYRIMIDINE-4-CARBOXAMIDE, LEUR PROCÉDÉ DE PRÉPARATION ET COMPOSITION PHARMACEUTIQUE LES COMPRENANT
Abstract: front page image
(EN)Provided are picolinamide and pyrimidine-4-carboxamide compounds, a method for preparing the same, a pharmaceutical composition containing the same, and a medical use using the compound as an agent for preventing, regulating, and treating diseases related to regulation of glucocorticoids by using selective inhibitory activity of the compound for an 11β-HSD1 enzyme. The picolinamide and pyrimidine-4-carboxamide compounds of the present invention are selective inhibitors of human-derived 11β-HSD1 enzymes, and are useful in an agent for preventing, regulating, and treating diseases related to glucocorticoid regulation in which human- derived 11β-HSD1 enzymes are involved, for example, metabolic syndromes such as, type 1 and type 2 diabetes, diabetes later complications, latent autoimmune diabetes adult (LAD A), insulin tolerance syndromes, obesity, impaired glucose tolerane (IGT), impaired fasting glucose (IFG), damaged glucose tolerance, dyslipidemia, atherosclerosis, hypertension, etc.
(FR)La présente invention concerne des composés de picolinamide et de pyrimidine-4-carboxamide, un procédé pour les préparer, une composition pharmaceutique les comprenant, et une utilisation médicale faisant appel à ces composés en tant qu'agent destiné à prévenir, réguler, et traiter des maladies liées à la régulation des glucocorticoïdes au moyen de l'activité inhibitrice sélective du composé vis-à-vis d'une enzyme 11β-HSD1. Les composés de picolinamide et de pyrimidine-4-carboxamide de la présente invention sont des inhibiteurs sélectifs des enzymes 11β-HSD1 d'origine humaine, et sont utiles dans un agent destiné à prévenir, réguler, et traiter des maladies liées à la régulation des glucocorticoïdes dans lesquelles interviennent les enzymes 11β-HSD1 d'origine humaine, par exemple les syndromes métaboliques tels que le diabète de type 1 et de type 2, les complications tardives du diabète, le diabète de type 1 latent chez l'adulte (LADA), les syndromes de tolérance à l'insuline, l'obésité, l'intolérance au glucose (IGT), la diminution de la glycémie à jeun (IFG), la diminution de la tolérance au glucose, la dyslipidémie, l'athérosclérose, l'hypertension, etc.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)