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Machine translation
1. (WO2011138641) A CONSTRUCT COMPRISING A NI AND/OR AU SUBSTRATE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/138641    International Application No.:    PCT/IB2010/051975
Publication Date: 10.11.2011 International Filing Date: 05.05.2010
IPC:
G01N 33/553 (2006.01), C07K 17/14 (2006.01), C07K 14/31 (2006.01), C07K 14/315 (2006.01)
Applicants: SANITARIA SCALIGERA SRL [IT/IT]; Via della Consortia 2 I-37127 Verona (IT) (For All Designated States Except US).
ZUCCATO, Alessandro [IT/IT]; (IT) (For US Only).
FACCI, Paolo [IT/IT]; (IT) (For US Only).
ALESSANDRINI, Andrea [IT/IT]; (IT) (For US Only)
Inventors: ZUCCATO, Alessandro; (IT).
FACCI, Paolo; (IT).
ALESSANDRINI, Andrea; (IT)
Agent: SANDRI, ING. SANDRO; Via Locatelli, 20 I-37122 Verona (IT)
Priority Data:
Title (EN) A CONSTRUCT COMPRISING A NI AND/OR AU SUBSTRATE
(FR) PRODUIT DE SYNTHÈSE COMPRENANT UN SUBSTRAT NI ET/OU AU
Abstract: front page image
(EN)A construct comprising a Ni and/or Au substrate provided of hexa-histidine-tagged protein A or G suitable for building a layer of antibodies featuring an enhanced antigen binding ability, wherein said hexa-histidine- tagged protein A or G is self-assembled in a monolayer on said Ni and/or substrate by the high affinity of the 6Xhis tag for the specified metal, whereby said protein binds the surface of the substrate only with the 6xhis tail, thereby orienting said hexa-histidine-tagged protein A or G in a predetermined fashion.
(FR)L'invention concerne un produit de synthèse comprenant un substrat Ni et/ou Au pourvu d'une protéine A ou G à étiquette d'hexahistidine adéquate pour la construction d'une couche d'anticorps présentant une capacité renforcée de liaison à un antigène, ladite protéine A ou G à étiquette d'hexahistidine étant autoassemblée dans une monocouche sur ledit substrat Ni et/ou Au en raison de la forte affinité de l'étiquette 6Xhis pour le métal spécifié, ladite protéine se liant à la surface du substrat seulement avec la queue 6xhis, orientant ainsi ladite protéine A ou G à étiquette d'hexahistidine d'une façon prédéterminée.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)