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Machine translation
1. (WO2011138293) 2,5,6,7-TETRAHYDRO-[1,4]OXAZEPIN-3-YLAMINE OR 2,3,6,7-TETRAHYDRO-[1,4]OXAZEPIN-5-YLAMINE COMPOUNDS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/138293    International Application No.:    PCT/EP2011/056990
Publication Date: 10.11.2011 International Filing Date: 03.05.2011
IPC:
C07D 267/10 (2006.01), C07D 413/12 (2006.01), C07D 417/12 (2006.01), A61K 31/553 (2006.01), A61P 25/28 (2006.01)
Applicants: F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124 CH-4070 Basel (CH) (For All Designated States Except US).
SIENA BIOTECH S.P.A. [IT/IT]; Strada del Petriccio e Belriguardo 35 I-53100 Siena (IT) (For All Designated States Except US).
BANNER, David [GB/CH]; (CH) (For US Only).
GUBA, Wolfgang [DE/DE]; (DE) (For US Only).
HILPERT, Hans [CH/CH]; (CH) (For US Only).
HUMM, Roland [DE/DE]; (DE) (For US Only).
MAUSER, Harald [DE/CH]; (CH) (For US Only).
MAYWEG, Alexander, V. [DE/CH]; (CH) (For US Only).
NARQUIZIAN, Robert [FR/FR]; (FR) (For US Only).
POWER, Eoin [IE/IE]; (IE) (For US Only).
ROGERS-EVANS, Mark [GB/CH]; (CH) (For US Only).
ROMBACH, Didier [FR/FR]; (FR) (For US Only).
WOLTERING, Thomas [DE/DE]; (DE) (For US Only).
WOSTL, Wolfgang [DE/DE]; (DE) (For US Only)
Inventors: BANNER, David; (CH).
GUBA, Wolfgang; (DE).
HILPERT, Hans; (CH).
HUMM, Roland; (DE).
MAUSER, Harald; (CH).
MAYWEG, Alexander, V.; (CH).
NARQUIZIAN, Robert; (FR).
POWER, Eoin; (IE).
ROGERS-EVANS, Mark; (CH).
ROMBACH, Didier; (FR).
WOLTERING, Thomas; (DE).
WOSTL, Wolfgang; (DE)
Agent: MUELLER-AFRAZ, Simona; Grenzacherstrasse 124 CH-4070 Basel (CH)
Priority Data:
10162340.3 07.05.2010 EP
Title (EN) 2,5,6,7-TETRAHYDRO-[1,4]OXAZEPIN-3-YLAMINE OR 2,3,6,7-TETRAHYDRO-[1,4]OXAZEPIN-5-YLAMINE COMPOUNDS
(FR) COMPOSÉS DE 2,5,6,7-TÉTRAHYDRO-[1,4]OXAZÉPIN-3-YLAMINE OU DE 2,3,6,7-TÉTRAHYDRO-[1,4]OXAZÉPIN-5-YLAMINE
Abstract: front page image
(EN)This invention relates to compounds of the formula (I), wherein A, B and R1 to R7 are as described below, or to pharmaceutically acceptable salts thereof. These compounds are BACE1 and/or BACE2 inhibitors and can be used as 5 medicaments for the therapeutic and/or prophylactic treatment of diseases such as Alzheimer's disease, diabetes, particularly type 2 diabetes, and other metabolic disorders.
(FR)L'invention concerne des composés représentés par la formule (I) dans laquelle A, B et R1 à R7 sont tels que décrits ci-après, ou des sels de ceux-ci pharmaceutiquement acceptables. Ces composés sont des inhibiteurs de BACE1 et/ou de BACE2 et peuvent être utilisés comme médicaments pour le traitement thérapeutique et/ou prophylactique de maladies, telles que la maladie d'Alzheimer, le diabète, en particulier le diabète de type 2, et d'autres troubles métaboliques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)