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1. (WO2011137322) METHODS AND COMPOSITIONS FOR TREATING CELIAC DISEASE

Pub. No.:    WO/2011/137322    International Application No.:    PCT/US2011/034516
Publication Date: Fri Nov 04 00:59:59 CET 2011 International Filing Date: Sat Apr 30 01:59:59 CEST 2011
IPC: A61K 39/395
Applicants: BETH ISRAEL DEACONNESS MEDICAL CENTER
SCHUPPAN, Detlef
JUNKER, Yvonne
LIBERMANN, Towia
DILLON, Simon, T.
Inventors: SCHUPPAN, Detlef
JUNKER, Yvonne
LIBERMANN, Towia
DILLON, Simon, T.
Title: METHODS AND COMPOSITIONS FOR TREATING CELIAC DISEASE
Abstract:
The invention features the treatment of gastrointestinal disorders associated with an innate immune response triggered by alpha amylase inhibitor CM3, alpha amylase inhibitor 0.19 (0.19), CMl, CM2, CMa, CMd, CM 16, CMb, CMX1/CMX3, CMX2, and/or alpha amylase inhibitor 0.53 (0.53). To this end, the invention features pharmaceutical compositions including neutralizing antibodies to CM3, 0.19, CMl, CM2, CMa, CMd, CM16, CMb, CMX1/CMX3, CMX2, and/or 0.53, food products containing reduced levels of CM3, 0.19, CMl, CM2, CMa, CMd, CMl 6, CMb, CMX1/CMX3, CMX2, and/or 0.53 protein, the use of oral TLR4 inhibitors to block the effect of said alpha-amylase inhibitors, assays for identifying CM3, 0.19, CMl, CM2, CMa, CMd, CM16, CMb, CMX1/CMX3, CMX2, and/or 0.53 content in food products, and assays for diagnosing subjects with a disorder related to CM3, 0.19, CMl, CM2, CMa, CMd, CM 16, CMb, CMX1/CMX3, CMX2, and/or 0.53 triggered innate immune responses.