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1. (WO2011137089) ACTIVATORS OF HUMAN PYRUVATE KINASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/137089    International Application No.:    PCT/US2011/033852
Publication Date: 03.11.2011 International Filing Date: 26.04.2011
IPC:
C07D 209/30 (2006.01), C07D 215/36 (2006.01), C07D 223/16 (2006.01), C07D 265/36 (2006.01), A61K 31/404 (2006.01), A61K 31/4704 (2006.01), A61K 31/538 (2006.01), A61K 31/55 (2006.01), A61P 35/00 (2006.01)
Applicants: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES [US/US]; Office of Technology Transfer, NIH 6011 Executive Boulevard, Suite 325 MSC 7600 Bethesda, Maryland 20892-7660 (US) (For All Designated States Except US).
BOXER, Matthew, B. [US/US]; (US) (For US Only).
SHEN, Min [CN/US]; (US) (For US Only).
AULD, Douglas, S. [US/US]; (US) (For US Only).
THOMAS, Craig, J. [US/US]; (US) (For US Only).
WALSH, Martin, J. [US/US]; (US) (For US Only)
Inventors: BOXER, Matthew, B.; (US).
SHEN, Min; (US).
AULD, Douglas, S.; (US).
THOMAS, Craig, J.; (US).
WALSH, Martin, J.; (US)
Agent: PILLAI, Xavier; LEYDIG, VOIT & MAYER, LTD. Two Prudential Plaza, Suite 4900 180 N. Stetson Avenue Chicago, Illinois 60601 (US)
Priority Data:
61/329,158 29.04.2010 US
Title (EN) ACTIVATORS OF HUMAN PYRUVATE KINASE
(FR) ACTIVATEURS DE LA PYRUVATE KINASE HUMAINE
Abstract: front page image
(EN)Disclosed are pyruvate kinase M2 activators which are compounds of Formula (I), including those of Formula (II), wherein A1, A2, L, R, R1 to R3, X1 to X3, k, n, and m are as defined herein, that are useful in treating a number of diseases that are treatable by the activation of PKM2, for example, cancer. A1 -NR-L-A2 (I)
(FR)L'invention concerne des activateurs de la pyruvate kinase M2 qui sont des composés de la formule (I), comprenant ceux de la formule (II), A1, A2, L, R, R1 à R3, X1 à X3, k, n étant tels que définis par les présentes, qui sont utiles dans le traitement de nombreuses maladies qui peuvent être traitées par l'activation de PKM2, par exemple les cancers. A1 -NR-L-A2 (I).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)