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Pub. No.:    WO/2011/136911    International Application No.:    PCT/US2011/031829
Publication Date: 03.11.2011 International Filing Date: 08.04.2011
C07K 16/32 (2006.01), A61K 39/395 (2006.01), A61P 35/00 (2006.01), C12N 15/13 (2006.01)
Applicants: AVEO PHARMACEUTICALS, INC. [US/US]; 75 Sidney Street, Fourth Floor Cambridge, MA 02139 (US) (For All Designated States Except US).
VINCENT, Sylvie [FR/US]; (US) (For US Only).
WINSTON, William, M., Jr. [US/US]; (US) (For US Only).
WANG, Fang [CN/US]; (US) (For US Only).
WEILER, Solly [US/US]; (US) (For US Only).
MEETZE, Kristan [US/US]; (US) (For US Only).
BREAULT, Lyne [CA/US]; (US) (For US Only).
BOTTEGA, Steve [CA/US]; (US) (For US Only).
CHEN, Ting [US/US]; (US) (For US Only).
DEPRIMA, Michael [US/US]; (US) (For US Only).
FLEET, Christina [US/US]; (US) (For US Only).
TYLER, Steven [US/US]; (US) (For US Only).
WOO, Jin-Kyeung [CN/US]; (US) (For US Only).
GYURIS, Jeno [HU/US]; (US) (For US Only)
Inventors: VINCENT, Sylvie; (US).
WINSTON, William, M., Jr.; (US).
WANG, Fang; (US).
WEILER, Solly; (US).
MEETZE, Kristan; (US).
BREAULT, Lyne; (US).
BOTTEGA, Steve; (US).
CHEN, Ting; (US).
DEPRIMA, Michael; (US).
FLEET, Christina; (US).
TYLER, Steven; (US).
WOO, Jin-Kyeung; (US).
GYURIS, Jeno; (US)
Agent: STERN-DOMBAL, Charlene, A.; Goodwin Procter LLP Exchange Place Boston, MA 02109 (US)
Priority Data:
61/322,712 09.04.2010 US
Abstract: front page image
(EN)Monoclonal antibodies that bind and inhibit activation of epidermal growth factor receptor related member ErbB3/HER3 are disclosed. The antibodies can be used to treat cell proliferative diseases and disorders, including certain forms of cancer, associated with activation of ErbB 3/HER3.
(FR)La présente invention a pour objet des anticorps monoclonaux qui se lient à l'élément ErbB3/HER3 associé au récepteur du facteur de croissance épidermique et inhibent son activation. Les anticorps peuvent être utilisés pour traiter des maladies et des troubles prolifératifs cellulaires, comprenant certaines formes de cancer, associés à l'activation d'ErbB3/HER3.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)