WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2011136645) FUSED CYCLOOCTYNE COMPOUNDS AND THEIR USE IN METAL-FREE CLICK REACTIONS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/136645    International Application No.:    PCT/NL2011/050280
Publication Date: 03.11.2011 International Filing Date: 26.04.2011
IPC:
C07C 33/16 (2006.01), C07C 69/96 (2006.01), A61K 47/48 (2006.01), A61K 49/00 (2006.01), G01N 33/531 (2006.01), G01N 33/68 (2006.01)
Applicants: SYNAFFIX B.V. [NL/NL]; Heyendaalseweg 135 NL-6525 AJ Nijmegen (NL) (For All Designated States Except US).
VAN DELFT, Floris, Louis [NL/NL]; (NL) (For US Only).
RUTJES, FLORIS PETRUS JOHANNES THEODORUS [NL/NL]; (NL) (For US Only).
Dommerholt, Frederik, Jan [NL/NL]; (NL) (For US Only)
Inventors: VAN DELFT, Floris, Louis; (NL).
RUTJES, FLORIS PETRUS JOHANNES THEODORUS; (NL).
Dommerholt, Frederik, Jan; (NL)
Agent: VAN WESTENBRUGGE, Andre; J.W. Frisolaan 13 NL-2517 JS The Hague (NL)
Priority Data:
10161192.9 27.04.2010 EP
61/328,306 27.04.2010 US
Title (EN) FUSED CYCLOOCTYNE COMPOUNDS AND THEIR USE IN METAL-FREE CLICK REACTIONS
(FR) COMPOSÉS DE CYCLOOCTYNE CONDENSÉS ET LEUR UTILISATION DANS DES RÉACTIONS DE CLICK SANS MÉTAL
Abstract: front page image
(EN)The invention relates to fused cyclooctyne compounds, and to a method for their preparation. The invention also relates to a conjugate wherein a fused cyclooctyne compound according to the invention is conjugated to a label,and to the use of these conjugates in bioorthogonal labeling, imaging and/or modification, such as for example surface modification,of a target molecule. The invention further relates to a method for the modification of a target molecule, wherein a conjugate according to the invention is reacted with a compound comprising a 1,3-dipole or a 1,3-(hetero)diene.
(FR)L'invention concerne des composés de cyclooctyne condensés, et un procédé pour leur préparation. L'invention concerne en outre un conjugué dans lequel un composé de cyclooctyne condensé selon l'invention est conjugué à un marqueur, et l'utilisation de ces conjugués dans un marquage bioorthogonal, l'imagerie et/ou une modification, telle que, par exemple, une modification de surface, d'une molécule cible. L'invention concerne en outre un procédé pour la modification d'une molécule cible, où un conjugué selon l'invention réagit avec un composé comprenant un 1,3-dipôle ou un 1,3-(hétéro)diène.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)