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Pub. No.:    WO/2011/136174    International Application No.:    PCT/JP2011/060059
Publication Date: 03.11.2011 International Filing Date: 25.04.2011
C07K 11/02 (2006.01), A61K 38/00 (2006.01), A61P 31/10 (2006.01), C12N 1/20 (2006.01), C12R 1/01 (2006.01)
Applicants: Astellas Pharma Inc. [JP/JP]; 3-11, Nihonbashi-Honcho 2-chome, Chuo-ku, Tokyo 1038411 (JP) (For All Designated States Except US).
KAI, Hirohito [JP/JP]; (JP) (For US Only).
YAMASHITA, Midori [JP/JP]; (JP) (For US Only).
NAKAMURA, Ikuko [JP/JP]; (JP) (For US Only).
EZAKI, Masami [JP/JP]; (JP) (For US Only).
NITTA, Kumiko [JP/JP]; (JP) (For US Only)
Inventors: KAI, Hirohito; (JP).
YAMASHITA, Midori; (JP).
NAKAMURA, Ikuko; (JP).
EZAKI, Masami; (JP).
NITTA, Kumiko; (JP)
Agent: MORITA, Hiroshi; c/o Astellas Pharma Inc. Intellectual Property, 3-11, Nihonbashi-Honcho 2-chome, Chuo-ku, Tokyo 1038411 (JP)
Priority Data:
2010-102297 27.04.2010 JP
(JA) デプシペプチド化合物
Abstract: front page image
(EN)Disclosed is a compound that is useful as an antifungal agent. In order to investigate the compounds that a microorganism produces, microorganisms in the genus Paenibacillus were sampled, and from the culture medium thereof, a depsipeptide compound or a salt thereof was isolated. It was confirmed that the depsipeptide compound has an antifungal effect, completing the present disclosures. The depsipeptide compound or a salt thereof has an antifungal effect, and may be used as a prevention and/or treatment agent for fungal disease.
(FR)L'invention porte sur un composé qui est utile comme agent antifongique. Afin de rechercher les composés qu'un microorganisme produit, des microorganismes du genre Paenibacillus ont été prélevés et à partir du milieu de culture de ceux-ci, un composé de depsipeptide ou un sel de celui-ci a été isolé. Il a été confirmé que le composé de depsipeptide possède un effet antifongique, ce qui permet de compléter la présente description. Le composé de depsipeptide ou un sel de celui-ci possède un effet antifongique et peut être utilisé comme agent préventif et/ou de traitement contre des maladies fongiques.
(JA)【課題】抗真菌剤として有用な化合物の提供。 【解決手段】本発明者らは、微生物の生産する化合物について検討するため、パエニバシルス(Paenibacillus)属の微生物を採取し、その培養液からデプシペプチド化合物またはその塩を単離した。本発明のデプシペプチド化合物が抗真菌作用を有することを確認し、本発明を完成した。本発明のデプシペプチド化合物またはその塩は、抗真菌作用を有し、真菌症の予防および/または治療剤として使用しうる。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)