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1. (WO2011135351) NAPHTHRIDINE DERIVATIVES AS PI3K INHIBITORS FOR THE TREATMENT OF CANCER AND IMMUNE - INFLAMMATORY DISEASES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/135351    International Application No.:    PCT/GB2011/050824
Publication Date: 03.11.2011 International Filing Date: 26.04.2011
IPC:
C07D 471/04 (2006.01), A61K 31/4375 (2006.01), A61P 29/00 (2006.01), A61P 35/00 (2006.01), A61P 37/00 (2006.01)
Applicants: KARUS THERAPEUTICS LIMITED [GB/GB]; Southampton Science Park 2 Venture Road, Chilworth Southampton Hampshire SO16 7NP (GB) (For All Designated States Except US).
SHUTTLEWORTH, Stephen, Joseph [GB/GB]; (GB) (For US Only).
SILVA, Franck, Alexandre [FR/GB]; (GB) (For US Only)
Inventors: SHUTTLEWORTH, Stephen, Joseph; (GB).
SILVA, Franck, Alexandre; (GB)
Agent: PERRY, Robert, Edward; Gill Jennings & Every LLP The Broadgate Tower 20 Primrose Street London Greater London EC2A 2ES (GB)
Priority Data:
1007347.6 30.04.2010 GB
Title (EN) NAPHTHRIDINE DERIVATIVES AS PI3K INHIBITORS FOR THE TREATMENT OF CANCER AND IMMUNE - INFLAMMATORY DISEASES
(FR) DÉRIVÉS DE NAPHTRIDINE EN TANT QU'INHIBITEURS DE PI3K POUR LE TRAITEMENT DU CANCER ET DE MALADIES IMMUNO-INFLAMMATOIRES
Abstract: front page image
(EN)Compounds of formulae (I) and (II): or a pharmaceutically acceptable salt thereof, wherein: R1 is a nitrogen-containing 5 to 7-membered heteroaryl or heterocycle; R2 and R3 are each independently (LQ)mY, are described. The compounds are PI3K inhibitors and are useful for the treatment of cancer and immune-inflammatory diseases.
(FR)La présente invention concerne des composés de formules (I) et (II) : ou un sel pharmaceutiquement acceptable de ceux-ci, où : R1 est un hétéroaryle ou hétérocycle de 5 à 7 chaînons contenant de l'azote; R2 et R3 sont chacun indépendamment (LQ)mY. Les composés sont des inhibiteurs de PI3K et sont utiles pour le traitement du cancer et de maladies immuno-inflammatoires.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)