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1. (WO2011135141) MODIFIED OLIGONUCLEOTIDES AS REGULATORS OF GENE EXPRESSION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/135141    International Application No.:    PCT/ES2011/070296
Publication Date: 03.11.2011 International Filing Date: 26.04.2011
IPC:
A61K 48/00 (2006.01), A61K 47/48 (2006.01), C12N 15/87 (2006.01)
Applicants: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC) [ES/ES]; Serrano, 117 E-28006 Madrid (ES) (For All Designated States Except US).
CIBER-BBN [ES/ES]; Campus Rio Ebro. Edificio I+D Bloque 5. 1ª Planta. Poeta Mariano Esquilor s/n E-50018 Zaragoza (ES) (For All Designated States Except US).
SOMOZA CALATRAVA, Álvaro [ES/ES]; (ES) (For US Only).
MANNING, Brendan [IE/ES]; (ES) (For US Only).
ERITJA CASADELLÁ, Ramón [ES/ES]; (ES) (For US Only).
TERRAZAS MARTÍNEZ, Montserrat [ES/ES]; (ES) (For US Only).
OCAMPO, Sandra Milena [CO/ES]; (ES) (For US Only).
AVIÑÓ ANDRÉS, Ana [ES/ES]; (ES) (For All Designated States Except US).
PERALES LOSA, José Carlos [ES/ES]; (ES) (For US Only)
Inventors: SOMOZA CALATRAVA, Álvaro; (ES).
MANNING, Brendan; (ES).
ERITJA CASADELLÁ, Ramón; (ES).
TERRAZAS MARTÍNEZ, Montserrat; (ES).
OCAMPO, Sandra Milena; (ES).
PERALES LOSA, José Carlos; (ES)
Agent: UNGRIA LÓPEZ, Javier; Avenida Ramón y Cajal, 78 E-28043 Madrid (ES)
Priority Data:
P201030614 27.04.2010 ES
Title (EN) MODIFIED OLIGONUCLEOTIDES AS REGULATORS OF GENE EXPRESSION
(ES) OLIGONUCLEÓTIDOS MODIFICADOS COMO REGULADORES DE LA EXPRESIÓN GÉNICA
(FR) OLIGONUCLÉOTIDES MODIFIÉS UTILISÉS COMME RÉGULATEURS DE L'EXPRESSION GÉNIQUE
Abstract: front page image
(EN)The invention relates to a compound of pARNi and a group R, where R is selected from alkyl, cycloalkyl, heterocycloalkyl, aryl and heteroaryl and to the synthesis processes thereof. The invention also relates to pharmaceutical compositions comprising the compounds according to the invention, and to the uses thereof in medicine.
(ES)La presente invención se refiere a un compuesto de pARNi y un grupo R, donde R se selecciona entre alquilo, cicloalquilo, heterocicloalquilo, arilo y heteroarilo y sus procesos de síntesis. Además también se describen composiciones farmacéuticas que comprenden los compuestos de la invención, así como sus usos en medicina.
(FR)La présente invention concerne un composé comprenant un pARNi et un groupe R, R étant choisi parmi alkyle, cycloalkyle, hétérocycloalkyle, aryle et hétéroaryle, et des procédés de synthèse correspondants. Des compositions pharmaceutiques comprenant les composés de l'invention, ainsi que leurs utilisations en médecine, sont également décrites.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Spanish (ES)
Filing Language: Spanish (ES)