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Machine translation
1. (WO2011134971) 7-(1H-PYRAZOL-4-YL)-1,6-NAPHTHYRIDINE COMPOUNDS AS SYK INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/134971    International Application No.:    PCT/EP2011/056600
Publication Date: 03.11.2011 International Filing Date: 27.04.2011
IPC:
C07D 471/04 (2006.01), A61K 31/4462 (2006.01), A61P 19/02 (2006.01)
Applicants: GLAXO GROUP LIMITED [GB/GB]; Glaxo Wellcome House Berkeley Avenue Greenford Middlesex UB6 0NN (GB) (For All Designated States Except US).
ATKINSON, Francis Louis [GB/GB]; (GB) (For US Only).
BARKER, Michael David [GB/GB]; (GB) (For US Only).
DOUAULT, Clement [FR/GB]; (GB) (For US Only).
GARTON, Neil Stuart [GB/GB]; (GB) (For US Only).
LIDDLE, John [GB/GB]; (GB) (For US Only).
PATEL, Vipulkumar Kantibhai [GB/GB]; (GB) (For US Only).
PRESTON, Alexander George Steven [GB/GB]; (GB) (For US Only).
WILSON, David Matthew [GB/GB]; (GB) (For US Only)
Inventors: ATKINSON, Francis Louis; (GB).
BARKER, Michael David; (GB).
DOUAULT, Clement; (GB).
GARTON, Neil Stuart; (GB).
LIDDLE, John; (GB).
PATEL, Vipulkumar Kantibhai; (GB).
PRESTON, Alexander George Steven; (GB).
WILSON, David Matthew; (GB)
Agent: PRICE, Susanna Clare Hopley; GlaxoSmithKline Global Patents (CN925.1) 980 Great West Road Brentford Middlesex TW8 9GS (GB)
Priority Data:
1007203.1 29.04.2010 GB
Title (EN) 7-(1H-PYRAZOL-4-YL)-1,6-NAPHTHYRIDINE COMPOUNDS AS SYK INHIBITORS
(FR) COMPOSÉS DE 7-(1H-PYRAZOL-4-YL)-1,6-NAPHTYRIDINE COMME INHIBITEURS DE SYK
Abstract: front page image
(EN)A compound of formula (I) or a salt thereof; which is an inhibitor of spleen tyrosine kinase (Syk) and therefore potentially of use in treating diseases resulting from inappropriate activation of mast and/or basophil cells, macrophages, and B-cells and related inflammatory responses and tissue damage, for instance inflammatory disease and/or allergic disorders, and in cancer therapy, specifically heme malignancies, chronic spontaneous urticaria and autoimmune conditions.
(FR)L'invention porte sur un composé de formule (I) ou un sel de celui-ci, qui est un inhibiteur de la tyrosine kinase de la rate (Syk) et par conséquent potentiellement utile dans le traitement de maladies résultant d'une activation inappropriée de mastocytes et/ou de cellules basophiles, de macrophages et de lymphocytes B et de réponses inflammatoires et d'un endommagement tissulaire apparentés, par exemple une maladie inflammatoire et/ou des troubles allergiques, et en thérapie anticancéreuse, en particulier les malignités hématologiques, l'urticaire spontanée chronique et les affections auto-immunes.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)