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1. (WO2011134060) ANTI-ICAM-1 SINGLE DOMAIN ANTIBODY AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/134060    International Application No.:    PCT/CA2011/000481
Publication Date: 03.11.2011 International Filing Date: 27.04.2011
IPC:
C07K 16/28 (2006.01), A61K 47/48 (2006.01), A61K 49/16 (2006.01), A61K 51/10 (2006.01), C12N 15/13 (2006.01)
Applicants: NATIONAL RESEARCH COUNCIL OF CANADA [CA/CA]; 1200 Montreal Road Ottawa, Ontario K1A 0R6 (CA) (For All Designated States Except US).
ABULROB, Abedelnasser [CA/CA]; (CA) (For US Only).
ARBABI-GHAHROUDI, Mehdi [CA/CA]; (CA) (For US Only).
STANIMIROVIC, Danica [CA/CA]; (CA) (For US Only)
Inventors: ABULROB, Abedelnasser; (CA).
ARBABI-GHAHROUDI, Mehdi; (CA).
STANIMIROVIC, Danica; (CA)
Agent: PATENAUDE, Sonia; National Research Council of Canada IP Portfolio Management 1200 Montreal Road Ottawa, Ontario K1A 0R6 (CA)
Priority Data:
61/328,406 27.04.2010 US
Title (EN) ANTI-ICAM-1 SINGLE DOMAIN ANTIBODY AND USES THEREOF
(FR) ANTICORPS À DOMAINE UNIQUE ANTI-ICAM-1 ET LEURS UTILISATIONS
Abstract: front page image
(EN)Anti-ICAM-1 VHH single-domain antibodies (sdAbs) are generated by immunizing a llama with recombinant ICAM-1. These antibodies are linked to an imaging moiety for in vivo or ex vivo imaging of ICAM-1 -related pathological conditions including atherosclerotic plaques. The antibodies may also be linked to a therapeutic agent to specifically target and treat ICAM-1 -related pathological conditions.
(FR)L'invention concerne des anticorps à domaine unique VHH anti-ICAM-1 (sdAb) qui sont générés par immunisation d'un lama avec un ICAM-1 recombinant. Ces anticorps sont liés à une fraction d'imagerie pour l'imagerie in vivo ou ex vivo d'états pathologiques liés à ICAM-1 comprenant les plaques d'athérosclérose. Les anticorps peuvent également être liés à un agent thérapeutique pour cibler spécifiquement et traiter des états pathologiques liés à ICAM-1.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)