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1. WO2011132713 - LIPID MEMBRANE STRUCTURE WITH NUCLEAR TRANSFERABILITY

Publication Number WO/2011/132713
Publication Date 27.10.2011
International Application No. PCT/JP2011/059738
International Filing Date 20.04.2011
IPC
A61K 9/127 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
127Liposomes
A61K 31/711 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
711Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 47/24 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
24containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
A61K 47/34 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
A61K 47/42 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
42Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
CPC
A61K 2039/5154
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
515Animal cells
5154Antigen presenting cells [APCs], e.g. dendritic cells, macrophages
A61K 2039/55555
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
555characterised by a specific combination antigen/adjuvant
55511Organic adjuvants
55555Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
A61K 31/711
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
711Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
A61K 39/39
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
39characterised by the immunostimulating additives, e.g. chemical adjuvants
A61K 47/50
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
A61K 47/62
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
62the modifying agent being a protein, peptide or polyamino acid
Applicants
  • 国立大学法人北海道大学 NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY [JP]/[JP] (AllExceptUS)
  • 国立大学法人京都大学 KYOTO UNIVERSITY [JP]/[JP] (AllExceptUS)
  • 原島 秀吉 HARASHIMA Hideyoshi (UsOnly)
  • 秋田 英万 AKITA Hidetaka (UsOnly)
  • シャリフ モハメド シャヒーン SHARIF Mohammad Shaheen (UsOnly)
  • 中村 孝司 NAKAMURA Takashi (UsOnly)
  • 石井 聡一郎 ISHII Soichiro (UsOnly)
  • 二木 史朗 FUTAKI Shiroh (UsOnly)
Inventors
  • 原島 秀吉 HARASHIMA Hideyoshi
  • 秋田 英万 AKITA Hidetaka
  • シャリフ モハメド シャヒーン SHARIF Mohammad Shaheen
  • 中村 孝司 NAKAMURA Takashi
  • 石井 聡一郎 ISHII Soichiro
  • 二木 史朗 FUTAKI Shiroh
Agents
  • 特許業務法人特許事務所サイクス SIKs & Co.
Priority Data
2010-09788821.04.2010JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) LIPID MEMBRANE STRUCTURE WITH NUCLEAR TRANSFERABILITY
(FR) STRUCTURE MEMBRANAIRE LIPIDIQUE AYANT UNE TRANSFÉRABILITÉ NUCLÉAIRE
(JA) 核内移行性を有する脂質膜構造体
Abstract
(EN)
Disclosed is a lipid membrane structure that can effectively deliver nucleic acid into a nucleus of immune cells such as dendritic cells. Specifically disclosed is a lipid membrane structure for delivering matter into a cell nucleus that has been modified with a polypeptide with an activity of promoting the transfer of lipid membrane structures into the cell nucleus, wherein the lipid membrane is a polypeptide from an amino acid sequence represented by (a) SEQ ID No. 1 and/or a polypeptide from an amino acid sequence represented by (b) SEQ ID No. 1 wherein one or several amino acids have been deleted and/or substituted and/or inserted.
(FR)
L'invention concerne une structure membranaire lipidique qui peut distribuer de manière efficace des acides nucléiques dans un noyau de cellules immunitaires telles que des cellules dendritiques. Spécifiquement, l'invention concerne une structure membranaire lipidique pour la distribution de matière dans un noyau cellulaire qui a été modifié par un polypeptide ayant une activité promotrice du transfert des structures membranaires lipidiques dans le noyau cellulaire, la membrane lipidique étant un polypeptide d'une séquence d'acides aminés représentée par (a) SEQ ID No. 1 et/ou un polypeptide d'une séquence d'acides aminés représentée par (b) SEQ ID No. 1 où un ou plusieurs acides aminés ont été supprimés et/ou substitués et/ou insérés.
(JA)
 樹状細胞などの免疫細胞の核内に核酸を効率的に送達することができる脂質膜構造体であって、脂質膜が下記の(a)配列番号1に記載のアミノ酸配列からなるポリペプチド及び/又は(b)配列番号1に記載のアミノ酸配列において1個又は数個のアミノ酸が欠失及び/又は置換及び/又は挿入されたアミノ酸配列からなるポリペプチドであって、細胞の核内への脂質膜構造体の移行を促進する活性を有するポリペプチドで修飾された細胞核内に物質を送達するための脂質膜構造体。
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