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1. (WO2011131749) NEW 14 AND 15 MEMBERED MACROLIDES FOR THE TREATMENT OF NEUTROPHIL DOMINATED INFLAMMATORY DISEASES

Pub. No.:    WO/2011/131749    International Application No.:    PCT/EP2011/056401
Publication Date: Fri Oct 28 01:59:59 CEST 2011 International Filing Date: Fri Apr 22 01:59:59 CEST 2011
IPC: C07H 17/08
A61K 31/7048
A61P 11/00
Applicants: GLAXO GROUP LIMITED
ALIHODZIC, Sulejman
ELENKOV, Ivaylo, Jivkov
POLJAK, Tanja
Inventors: ALIHODZIC, Sulejman
ELENKOV, Ivaylo, Jivkov
POLJAK, Tanja
Title: NEW 14 AND 15 MEMBERED MACROLIDES FOR THE TREATMENT OF NEUTROPHIL DOMINATED INFLAMMATORY DISEASES
Abstract:
(E)-11,12-Didehydro-11,12-dideoxy 14-membered macrolides and 15-membered azalide macrolides represented by Formula (I): useful in the treatment of neutrophil dominated inflammatory diseases, especially in the treatment of neutrophil dominated inflammatory diseases resulting from neutrophilic infiltration and/or diseases associated with altered cellular functionality of neutrophils, to intermediates for their preparation, to methods for their preparation, to their use as therapeutic agents, and to salts thereof.