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1. WO2011131749 - NEW 14 AND 15 MEMBERED MACROLIDES FOR THE TREATMENT OF NEUTROPHIL DOMINATED INFLAMMATORY DISEASES

Publication Number WO/2011/131749
Publication Date 27.10.2011
International Application No. PCT/EP2011/056401
International Filing Date 21.04.2011
IPC
C07H 17/08 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
17Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
04Heterocyclic radicals containing only oxygen as ring hetero atoms
08Hetero rings containing eight or more ring members, e.g. erythromycins
A61K 31/7048 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7048having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
A61P 11/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
CPC
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
C07H 17/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
17Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
04Heterocyclic radicals containing only oxygen as ring hetero atoms
08Hetero rings containing eight or more ring members, e.g. erythromycins
Applicants
  • GLAXO GROUP LIMITED [GB]/[GB] (AllExceptUS)
  • ALIHODZIC, Sulejman [HR]/[HR] (UsOnly)
  • ELENKOV, Ivaylo, Jivkov [HR]/[HR] (UsOnly)
  • POLJAK, Tanja [HR]/[HR] (UsOnly)
Inventors
  • ALIHODZIC, Sulejman
  • ELENKOV, Ivaylo, Jivkov
  • POLJAK, Tanja
Agents
  • CRAWLEY, Karen, A.
Priority Data
61/327,21223.04.2010US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) NEW 14 AND 15 MEMBERED MACROLIDES FOR THE TREATMENT OF NEUTROPHIL DOMINATED INFLAMMATORY DISEASES
(FR) NOUVEAUX MACROLIDES À 14 ET 15 CHAÎNONS POUR LE TRAITEMENT DE MALADIES INFLAMMATOIRES À DOMINANCE EN NEUTROPHILES
Abstract
(EN) (E)-11,12-Didehydro-11,12-dideoxy 14-membered macrolides and 15-membered azalide macrolides represented by Formula (I): useful in the treatment of neutrophil dominated inflammatory diseases, especially in the treatment of neutrophil dominated inflammatory diseases resulting from neutrophilic infiltration and/or diseases associated with altered cellular functionality of neutrophils, to intermediates for their preparation, to methods for their preparation, to their use as therapeutic agents, and to salts thereof.
(FR) L'invention concerne des (E)-11,12-didehydro-11,12-didéoxy macrolides à 14 chaînons et des macrolides de type azalide à 15 chaînons représentés par la Formule (I) : utiles dans le traitement de maladies inflammatoires à dominance en neutrophiles, particulièrement dans le traitement de maladies inflammatoires à dominance en neutrophiles résultant de l'infiltration de neutrophiles et/ou de maladies associées à une fonctionnalité cellulaire modifiée des neutrophiles. L'invention concerne également des intermédiaires pour leur préparation, des procédés pour leur préparation, leur utilisation comme agents thérapeutiques et des sels de ceux-ci.
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