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1. (WO2011131749) NEW 14 AND 15 MEMBERED MACROLIDES FOR THE TREATMENT OF NEUTROPHIL DOMINATED INFLAMMATORY DISEASES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/131749    International Application No.:    PCT/EP2011/056401
Publication Date: 27.10.2011 International Filing Date: 21.04.2011
IPC:
C07H 17/08 (2006.01), A61K 31/7048 (2006.01), A61P 11/00 (2006.01)
Applicants: GLAXO GROUP LIMITED [GB/GB]; Glaxo Wellcome House Berkeley Avenue Greenford Middlesex UB6 0NN (GB) (For All Designated States Except US).
ALIHODZIC, Sulejman [HR/HR]; (GB) (For US Only).
ELENKOV, Ivaylo, Jivkov [HR/HR]; (GB) (For US Only).
POLJAK, Tanja [HR/HR]; (GB) (For US Only)
Inventors: ALIHODZIC, Sulejman; (GB).
ELENKOV, Ivaylo, Jivkov; (GB).
POLJAK, Tanja; (GB)
Agent: CRAWLEY, Karen, A.; GlaxoSmithKline Global Patents CN925.1 980 Great West Road Brentford Middlesex TW8 9GS (GB)
Priority Data:
61/327,212 23.04.2010 US
Title (EN) NEW 14 AND 15 MEMBERED MACROLIDES FOR THE TREATMENT OF NEUTROPHIL DOMINATED INFLAMMATORY DISEASES
(FR) NOUVEAUX MACROLIDES À 14 ET 15 CHAÎNONS POUR LE TRAITEMENT DE MALADIES INFLAMMATOIRES À DOMINANCE EN NEUTROPHILES
Abstract: front page image
(EN)(E)-11,12-Didehydro-11,12-dideoxy 14-membered macrolides and 15-membered azalide macrolides represented by Formula (I): useful in the treatment of neutrophil dominated inflammatory diseases, especially in the treatment of neutrophil dominated inflammatory diseases resulting from neutrophilic infiltration and/or diseases associated with altered cellular functionality of neutrophils, to intermediates for their preparation, to methods for their preparation, to their use as therapeutic agents, and to salts thereof.
(FR)L'invention concerne des (E)-11,12-didehydro-11,12-didéoxy macrolides à 14 chaînons et des macrolides de type azalide à 15 chaînons représentés par la Formule (I) : utiles dans le traitement de maladies inflammatoires à dominance en neutrophiles, particulièrement dans le traitement de maladies inflammatoires à dominance en neutrophiles résultant de l'infiltration de neutrophiles et/ou de maladies associées à une fonctionnalité cellulaire modifiée des neutrophiles. L'invention concerne également des intermédiaires pour leur préparation, des procédés pour leur préparation, leur utilisation comme agents thérapeutiques et des sels de ceux-ci.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)