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1. (WO2011130677) INHIBITORS OF CANCER STEM CELLS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2011/130677 International Application No.: PCT/US2011/032750
Publication Date: 20.10.2011 International Filing Date: 15.04.2011
IPC:
A61P 35/00 (2006.01) ,A61K 31/382 (2006.01) ,A61K 31/4745 (2006.01) ,A61K 31/165 (2006.01) ,A61K 31/47 (2006.01) ,A61K 31/5375 (2006.01) ,A61K 31/352 (2006.01) ,A61K 31/473 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
38
having sulfur as a ring hetero atom
382
having six-membered rings, e.g. thioxanthenes
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
47
Quinolines; Isoquinolines
4738
ortho- or peri-condensed with heterocyclic ring systems
4745
condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenanthrolines
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
16
Amides, e.g. hydroxamic acids
165
having aromatic rings, e.g. colchicine, atenolol, progabide
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
47
Quinolines; Isoquinolines
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
535
having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
5375
1,4-Oxazines, e.g. morpholine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
35
having six-membered rings with one oxygen as the only ring hetero atom
352
condensed with carbocyclic rings, e.g. cannabinols, methantheline
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
47
Quinolines; Isoquinolines
473
ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
Applicants:
UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION [US/US]; 200 Gardner Steel Conference Center Thackeray and O'Hara Streets Pittsburgh, PA 15260, US (AllExceptUS)
LAZO, John, S. [US/US]; US (UsOnly)
ZHANG, Fang [CN/US]; US (UsOnly)
PROCHOWNIK, Edward, V. [US/US]; US (UsOnly)
Inventors:
LAZO, John, S.; US
ZHANG, Fang; US
PROCHOWNIK, Edward, V.; US
Agent:
NOONAN, William, D.; Klarquist Sparkman, LLP One World Trade Center, Suite 1600 121 SW Salmon Street Portland, OR 97204, US
Priority Data:
61/325,15616.04.2010US
61/325,70519.04.2010US
Title (EN) INHIBITORS OF CANCER STEM CELLS
(FR) INHIBITEURS DE CELLULES SOUCHES CANCÉREUSES
Abstract:
(EN) A method of treating cancer in a subject, comprising co-administering to the subject (a) a therapeutically effective amount of at least one compound that selectively targets cancer stem cells, wherein the compound is selected from an indenoisoquinoline compound, a naphthoquinone compound, a quinolinedione compound, bouvardin, A-77636, rottlerin, or CGP-74514A, or a pharmaceutically acceptable salt or ester thereof, and (b) a therapeutically effective amount of at least one anti-cancer agent.
(FR) L'invention concerne une méthode de traitement du cancer, chez un sujet, qui comporte la co-administration au sujet (a) d'une quantité thérapeutiquement efficace d'au moins un composé qui cible sélectivement les cellules souches cancéreuses, le composé étant choisi parmi un composé d'indénoisoquinoline, un composé de naphthoquinone, un composé de quinolinedione, la bouvardine, A-77636, la rottlerine, ou CGP-74514A, ou un sel ou un ester de qualité pharmaceutique de ceux-ci, et (b) d'une quantité thérapeutiquement efficace d'au moins un agent anticancéreux.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)