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1. WO2011130301 - METHOD OF DIAGNOSING AND TREATING MELIOIDOSIS

Publication Number WO/2011/130301
Publication Date 20.10.2011
International Application No. PCT/US2011/032155
International Filing Date 12.04.2011
IPC
G01N 33/53 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
G01N 33/15 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
15Medicinal preparations
A61K 39/02 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
02Bacterial antigens
A61P 31/04 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
CPC
A61P 31/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
C07K 16/1214
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
12against material from bacteria
1203from Gram-negative bacteria
1214from Pseudomonadaceae (F)
G01N 2333/21
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2333Assays involving biological materials from specific organisms or of a specific nature
195from bacteria
21from Pseudomonadaceae (F)
G01N 2800/52
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2800Detection or diagnosis of diseases
52Predicting or monitoring the response to treatment; Prognosis
G01N 33/56911
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
569for microorganisms, e.g. protozoa, bacteria, viruses
56911Bacteria
Applicants
  • THE BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION, ON BEHALF OF THE UNIVERSITY OF NEVADA, RENO [US]/[US] (AllExceptUS)
  • KOZEL, Thomas [US]/[US] (UsOnly)
  • AUCOIN, David [US]/[US] (UsOnly)
Inventors
  • KOZEL, Thomas
  • AUCOIN, David
Agents
  • BRADLEY, Karri, Kuenzli
Priority Data
61/323,23612.04.2010US
61/452,38814.03.2011US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHOD OF DIAGNOSING AND TREATING MELIOIDOSIS
(FR) PROCÉDÉ PERMETTANT DE DIAGNOSTIQUER ET DE TRAITER LA MÉLIOÏDOSE
Abstract
(EN) Non-invasive methods are provided herein for the diagnosis of melioidosis with specific antibodies capable of detecting molecules associated with melioidosis in a biological fluid, such as urine or serum. These molecules can be identified using proteomic methods, including but not limited to antibody based methods, such as an enzyme-linked immunosorbant assay (ELISA), a radioimmnoassay (RIA), or a lateral flow immunoassay. Methods of inducing an immune response to melioidosis are also disclosed. The methods include the use of the immunogenic melioidosis polypeptides, nucleic acids encoding these polypeptides, and/or viral vectors encoding an immunogenic melioidosis polypeptide, alone or in conjunction with other agents, such as traditional melioidosis therapies. Also disclosed are methods for treating a subject having melioidosis. These methods include inducing an immune response to melioidosis and/or using an inhibitory nucleic acid, such as a siRNA or antisense molecule, to decrease a melioidosis associated molecule expression in order to treat melioidosis.
(FR) L'invention concerne des procédés non invasifs permettant de diagnostiquer la mélioïdose avec des anticorps spécifiques pouvant détecter les molécules associées à la mélioïdose dans un fluide biologique, tel que l'urine ou du sérum. Selon l'invention, ces molécules peuvent être identifiées en utilisant des procédés protéomiques, comprenant sans s'y limiter des procédés basés sur les anticorps, tels que le dosage avec immunoabsorbant lié à une enzyme (ELISA), le dosage radioimmunologique (RIA), ou le dosage immunologique à flux latéral. L'invention concerne aussi des procédés d'induction d'une réponse immunitaire à la mélioïdose. Les procédés comprennent l'utilisation de polypeptides immunogéniques de mélioïdose, d'acides nucléiques codant ces polypeptides, et/ou de vecteurs viraux codant un polypeptide immunogénique de mélioïdose, seuls ou associés à d'autres agents, tels que les thérapies traditionnelles contre la mélioïdose. L'invention décrit aussi des procédés de traitement d'un sujet souffrant de mélioïdose. Ces procédés comprennent l'induction d'une réponse immunitaire à la mélioïdose et/ou l'utilisation d'un acide nucléique inhibiteur, tel qu'un ARNsi ou une molécule antisens, pour réduire l'expression d'une molécule associée à la mélioïdose dans le but de traiter la maladie.
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