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110. (WO2011130194) METHODS FOR PRODUCING VILOXAZINE SALTS AND NOVEL POLYMORPHS THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2011/130194 International Application No.: PCT/US2011/032013
Publication Date: 20.10.2011 International Filing Date: 12.04.2011
IPC:
C07C 217/54 (2006.01) ,C07D 265/30 (2006.01) ,C07D 265/32 (2006.01) ,A61K 31/5375 (2006.01) ,A61P 25/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
217
Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
54
having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
265
Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
28
1,4-Oxazines; Hydrogenated 1,4-oxazines
30
not condensed with other rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
265
Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
28
1,4-Oxazines; Hydrogenated 1,4-oxazines
30
not condensed with other rings
32
with oxygen atoms directly attached to ring carbon atoms
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
535
having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
5375
1,4-Oxazines, e.g. morpholine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
Applicants:
LIANG, Likan [US/US]; US (UsOnly)
BHATT, Padmanabh P. [US/US]; US (UsOnly)
DAIN, David [US/US]; US (UsOnly)
TAQUET, Jean-Philippe [FR/FR]; FR (UsOnly)
PECHENOV, Aleksandr [RU/US]; US (UsOnly)
TCHESNOKOV, Alexei [RU/US]; US (UsOnly)
MARIAUX, Reynold [CH/CH]; CH (UsOnly)
SUPERNUS PHARMACEUTICALS INC. [US/US]; 1550 East Gude Drive Rockville, Maryland 20850, US (AllExceptUS)
Inventors:
LIANG, Likan; US
BHATT, Padmanabh P.; US
DAIN, David; US
TAQUET, Jean-Philippe; FR
PECHENOV, Aleksandr; US
TCHESNOKOV, Alexei; US
MARIAUX, Reynold; CH
Agent:
JULIAN-ARNOLD, Gianna; 500 East Pratt Street Suite 900 Baltimore, Maryland 21201, US
Priority Data:
61/323,15112.04.2010US
Title (EN) METHODS FOR PRODUCING VILOXAZINE SALTS AND NOVEL POLYMORPHS THEREOF
(FR) PROCÉDÉS DE FABRICATION DE SELS DE VILOXAZINE ET LEURS NOUVEAUX POLYMORPHES
Abstract:
(EN) Provided here are methods of manufacture of viloxazine and its various salts, as well as viloxazine-related compounds, such as novel intermediate reaction products and polymorphs thereof. In particular, the methods provide a substantially pure API of viloxazine HC1 while avoiding undesirable impurities. The methods further provide for separating, identifying, and characterizing novel polymorphs of viloxazine. Further provided are methods for synthesis and identification and characterization of novel intermediates of viloxazine, as well as for some important metabolites and precursors of metabolites of viloxazine.
(FR) L'invention concerne des procédés de fabrication de viloxazine et de ses divers sels, ainsi que des composés apparentés à la viloxazine, tels que de nouveaux produits réactionnels intermédiaires et des polymorphes de celle-ci. En particulier, les procédés fournissent un Ingrédient Pharmaceutique Actif (API) sensiblement pur de viloxazine HCl tout en évitant des impuretés non désirables. Les procédés concernent en outre la séparation, l'identification et la caractérisation de nouveaux polymorphes de viloxazine. L'invention concerne en outre des procédés de synthèse et d'identification et de caractérisation de nouveaux intermédiaires de viloxazine, ainsi que certains métabolites et précurseurs de métabolites importants de viloxazine.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)