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1. WO2011129649 - MICROFLUIDIC DEVICE AND METHOD FOR ISOLATING TARGET USING SAME

Publication Number WO/2011/129649
Publication Date 20.10.2011
International Application No. PCT/KR2011/002703
International Filing Date 15.04.2011
IPC
G01N 33/49 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
483Physical analysis of biological material
487of liquid biological material
49blood
G01N 33/53 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
G01N 35/00 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
35Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/-G01N33/148; Handling materials therefor
C12M 1/12 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
12with sterilisation, filtration, or dialysis means
CPC
B01L 3/502753
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3Containers or dishes for laboratory use, e.g. laboratory glassware
50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
502with fluid transport, e.g. in multi-compartment structures
5027by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
502753characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
G01N 2035/00158
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
35Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
00029provided with flat sample substrates, e.g. slides
00099Characterised by type of test elements
00158Elements containing microarrays, i.e. "biochip"
G01N 2035/1053
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
35Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
10Devices for transferring samples ; or any liquids; to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
1027General features of the devices
1048using the transfer device for another function
1053for separating part of the liquid, e.g. filters, extraction phase
G01N 33/491
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
483Physical analysis of biological material
487of liquid biological material
49Blood
491by separating the blood components
G01N 35/1095
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
35Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
10Devices for transferring samples ; or any liquids; to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
1095for supplying the samples to flow-through analysers
Applicants
  • 주식회사 싸이토젠 CYTOGEN CO., LTD. [KR]/[KR] (AllExceptUS)
  • 전병희 JEON, Byung Hee [KR]/[KR] (UsOnly)
Inventors
  • 전병희 JEON, Byung Hee
Agents
  • 특허법인 다인 DYNE PATENT & LAW FIRM
Priority Data
10-2010-003500615.04.2010KR
Publication Language Korean (ko)
Filing Language Korean (KO)
Designated States
Title
(EN) MICROFLUIDIC DEVICE AND METHOD FOR ISOLATING TARGET USING SAME
(FR) DISPOSITIF MICROFLUIDIQUE ET PROCÉDÉ D'ISOLEMENT D'UNE CIBLE L'UTILISANT
(KO) 미세유체장치 및 이것을 이용한 타깃의 분리방법
Abstract
(EN) Disclosed is a microfluidic device for isolating targets from a sample and a method for isolating targets using same. The microfluidic device of the present invention comprises a first filtering unit, a carrier fluid supply unit, and a second filtering unit. The first filtering unit is provided such that a filter surface having a plurality of different types of targets filtered is facing the opposite direction from the filtering direction. The carrier fluid supply unit is provided upstream of the first filtering unit, and supplies to the first filtering unit a carrier fluid that transports the plurality of different types of targets to downstream. The second filtering unit is provided downstream of the first filtering unit, and receives the plurality of different types of targets from the first filtering unit filtering same. The method for isolating targets according to the present invention uses pre-processing to remove non-targets from a plurality of non-targets and the plurality of different types of targets included in the sample, and uses post-processing to isolate the targets obtained in the pre-processing.
(FR) L'invention concerne un dispositif microfluidique destiné à isoler des cibles à partir d'un échantillon, ainsi qu'un procédé d'isolement de cibles l'utilisant. Le dispositif microfluidique selon la présente invention comporte une première unité de filtration, une unité d'alimentation en fluide porteur et une deuxième unité de filtration. La première unité de filtration est configurée de telle sorte qu'une surface filtrante assurant la filtration d'une pluralité de types de cibles différents est orientée dans la direction opposée à la direction de filtration. L'unité d'alimentation en fluide porteur est placée en amont de la première unité de filtration et fournit à la première unité de filtration un fluide porteur qui transporte la pluralité de types de cibles différents vers l'aval. La deuxième unité de filtration est placée en aval de la première unité de filtration et reçoit la pluralité de types de cibles différents provenant de la première unité de filtration qui assure leur filtration. Le procédé d'isolement de cibles selon la présente invention utilise un prétraitement pour éliminer des substances non ciblées parmi une pluralité de substances non ciblées et la pluralité de types de cibles différents comprises dans l'échantillon, et utilise un post-traitement pour isoler les cibles obtenues lors du prétraitement.
(KO) 본 발명은 샘플로부터 타깃을 분리하기 위한 미세유체장치 및 이것을 이용한 타깃의 분리방법을 개시한다. 본 발명에 따른 미세유체장치는 제1 필터링장치, 운반유체 공급장치와 제2 필터링장치로 구성되어 있다. 제1 필터링장치는 복수 유형의 타깃들이 여과되어 있는 여과면이 그 여과 방향과 반대 방향을 향하도록 배치되어 있다. 운반유체 공급장치는 제1 필터링장치의 상류에 장착되어 있고, 복수 유형의 타깃들을 하류로 수송하는 운반유체를 제1 필터링장치에 공급한다. 제2 필터링장치는 제1 필터링장치의 하류에 장착되어 있으며, 제1 필터링장치로부터 복수 유형의 타깃들을 받아들여 여과한다. 본 발명에 따른 타깃의 분리방법은 샘플에 포함되어 있는 복수의 논타깃들과 복수 유형의 타깃들 중 전처리에 의하여 논타깃들을 제거한 후, 전처리에서 획득한 타깃들을 후처리에 의하여 분리한다.
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