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1. WO2011123779 - CELL THERAPY TO IMPROVE WOUND HEALING AND RELATED COMPOSITIONS AND METHODS

Publication Number WO/2011/123779
Publication Date 06.10.2011
International Application No. PCT/US2011/030939
International Filing Date 01.04.2011
IPC
C12N 5/071 2010.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
CPC
A61K 35/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
14Blood; Artificial blood
A61K 35/48
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
48Reproductive organs
A61P 17/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
02for treating wounds, ulcers, burns, scars, keloids, or the like
C12N 5/0682
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor;
06Animal cells or tissues; Human cells or tissues
0602Vertebrate cells
0681Cells of the genital tract; Non-germinal cells from gonads
0682Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
Applicants
  • CRYO-CELL INTERNATIONAL, INC. [US]/[US] (AllExceptUS)
  • WALTON, Mercedes, A. [US]/[US] (UsOnly)
  • ALLICKSON, Julie, G. [US]/[US] (UsOnly)
  • GARCIA-MORALES, Rolando, O. [US]/[US] (UsOnly)
Inventors
  • WALTON, Mercedes, A.
  • ALLICKSON, Julie, G.
  • GARCIA-MORALES, Rolando, O.
Agents
  • CHISM, Dell, B.
Priority Data
61/341,65201.04.2010US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) CELL THERAPY TO IMPROVE WOUND HEALING AND RELATED COMPOSITIONS AND METHODS
(FR) THÉRAPIE CELLULAIRE POUR AMÉLIORER LA CICATRISATION DES PLAIES ET COMPOSITIONS ET MÉTHODES ASSOCIÉES
Abstract
(EN) Therapeutic compositions for improving wound healing and related methods of formulation and use are provided. The therapeutic compositions comprise a dosage of MSCs seeded to any one of a biodegradable matrix, a gel, or a solution suitable for subcutaneous injection. The dosage of MSCs may range from about 1X106 MSCs to about 1X1010 per administration. The administration regime may be daily, weekly, or monthly. The dosage and treatment intervals may be adjusted depending upon a patient's response to treatment. The therapeutic compositions may be co-administered, such as for example, topical application of a seeded matrix or gel combined with simultaneous or other recurring subcutaneous injection of MSCs.
(FR) La présente invention a pour objet des compositions thérapeutiques permettant d'améliorer la cicatrisation des plaies, des procédés de formulation associés et des méthodes d'utilisation associées. Les compositions thérapeutiques comprennent un dosage de MSC ensemencées,au choix, sur une matrice biodégradable, un gel, ou une solution convenant pour une injection sous-cutanée. Le dosage des MSC peut être compris dans une plage d'environ 1 X 106 MSC à environ 1 X 1010 par administration. Le régime d'administration peut être quotidien, hebdomadaire ou mensuel. Le dosage et les intervalles de traitement peuvent être ajustés en fonction de la réponse d'un patient au traitement. Les compositions thérapeutiques peuvent être co-administrées, par exemple, une application topique d'une matrice ou d'un gel ensemencé combinée à une injection sous-cutanée simultanée ou autrement périodique de MSC.
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