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1. WO2011123030 - NANOPARTICLES COMPRISING A CORE OF AMORPHOUS RARE EARTH ELEMENT HYDROXIDE AND AN ORGANIC COATING

Publication Number WO/2011/123030
Publication Date 06.10.2011
International Application No. PCT/SE2011/050345
International Filing Date 29.03.2011
IPC
A61K 49/18 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
06Nuclear magnetic resonance (NMR) contrast preparations; Magnetic resonance imaging (MRI) contrast preparations
18characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
A61K 51/12 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51Preparations containing radioactive substances for use in therapy or testing in vivo
12characterised by a special physical form, e.g. emulsion, microcapsules, liposomes
A61K 103/30 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
103Radioactive metals
30Rare earths
A61K 103/34 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
103Radioactive metals
30Rare earths
34Gadolinium
CPC
A61K 49/0002
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
0002General or multifunctional contrast agents, e.g. chelated agents
A61K 49/0021
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
001Preparation for luminescence or biological staining
0013Luminescence
0017Fluorescence in vivo
0019characterised by the fluorescent group
0021the fluorescent group being a small organic molecule
A61K 49/0039
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
001Preparation for luminescence or biological staining
0013Luminescence
0017Fluorescence in vivo
0019characterised by the fluorescent group
0021the fluorescent group being a small organic molecule
0039Coumarin dyes
A61K 49/0093
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
001Preparation for luminescence or biological staining
0063characterised by a special physical or galenical form, e.g. emulsions, microspheres
0069the agent being in a particular physical galenical form
0089Particulate, powder, adsorbate, bead, sphere
0091Microparticle, microcapsule, microbubble, microsphere, microbead, i.e. having a size or diameter higher or equal to 1 micrometer
0093Nanoparticle, nanocapsule, nanobubble, nanosphere, nanobead, i.e. having a size or diameter smaller than 1 micrometer, e.g. polymeric nanoparticle
A61K 49/0428
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
04X-ray contrast preparations
0409Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound
0414Particles, beads, capsules or spheres
0423Nanoparticles, nanobeads, nanospheres, nanocapsules, i.e. having a size or diameter smaller than 1 micrometer
0428Surface-modified nanoparticles, e.g. immuno-nanoparticles
A61K 49/1839
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
18characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
1818particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
1821coated or functionalised microparticles or nanoparticles
1824coated or functionalised nanoparticles
1827having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
1833having a (super)(para)magnetic core coated or functionalised with a small organic molecule
1839the small organic molecule being a lipid, a fatty acid having 8 or more carbon atoms in the main chain, or a phospholipid
Applicants
  • SPAGO IMAGING AB [SE]/[SE] (AllExceptUS)
  • AXELSSON, Oskar [SE]/[SE] (UsOnly)
  • EK, Fredrik [SE]/[SE] (UsOnly)
  • PETORAL JR, Rodrigo M. [PH]/[SE] (UsOnly)
Inventors
  • AXELSSON, Oskar
  • EK, Fredrik
  • PETORAL JR, Rodrigo M.
Agents
  • AWAPATENT AB
Priority Data
1050300-130.03.2010SE
61/318,82730.03.2010US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) NANOPARTICLES COMPRISING A CORE OF AMORPHOUS RARE EARTH ELEMENT HYDROXIDE AND AN ORGANIC COATING
(FR) NANOPARTICULES COMPRENANT UN CŒUR D'HYDROXYDE D'ÉLÉMENT TERRE RARE AMORPHE ET UNE ÉCORCE ORGANIQUE
Abstract
(EN) The present invention relates to paramagnetic nanoparticles which may be used as contrast agents for visualizing or imaging biological material. Said nanoparicles comprise a core of amorphous rare earth element hydroxide, and an organic coating comprising silicon atoms and phosphorus atoms. Preferably, the coating comprises an oriented monolayer of one or more organo-oxysilane residue(s). A second silane, binding in between the larger organo-oxysilane, may be added in order to stabilize the coating. Methods for preparing said nanoparticles are also disclosed.
(FR) La présente invention concerne des nanoparticules paramagnétiques qui peuvent être utilisées comme agents de contraste pour visualiser ou réaliser l'imagerie d'un matériel biologique. Lesdites nanoparticules comprennent un cœur d'hydroxyde d'élément terre rare amorphe et une écorce organique comprenant des atomes de silicium et des atomes de phosphore. De préférence, l'écorce comprend une monocouche orientée d'un ou plusieurs résidus organo-oxysilanes. Un second silane, se liant entre les organo-oxysilanes plus grands, peut être ajouté afin de stabiliser l'écorce. L'invention concerne des procédés de préparation desdites nanoparticules.
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