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1. WO2011117653 - DISULFIDE STABILIZED DVD-LG MOLECULES

Publication Number WO/2011/117653
Publication Date 29.09.2011
International Application No. PCT/GB2011/050613
International Filing Date 25.03.2011
IPC
C07K 16/46 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
46Hybrid immunoglobulins
CPC
C07K 16/468
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
46Hybrid immunoglobulins
468Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
C07K 2317/624
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
60characterized by non-natural combinations of immunoglobulin fragments
62comprising only variable region components
624Disulfide-stabilized antibody (dsFv)
C07K 2317/64
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
60characterized by non-natural combinations of immunoglobulin fragments
64comprising a combination of variable region and constant region components
C07K 2317/94
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
90characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
94Stability, e.g. half-life, pH, temperature or enzyme-resistance
C08G 59/066
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
59Polycondensates containing more than one epoxy group per molecule
02Polycondensates containing more than one epoxy group per molecule
04of polyhydroxy compounds with epihalohydrins or precursors thereof
06of polyhydric phenols
066with chain extension or advancing agents
C08G 59/145
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
59Polycondensates containing more than one epoxy group per molecule
14Polycondensates modified by chemical after-treatment
1433with organic low-molecular-weight compounds
1438containing oxygen
145Compounds containing one epoxy group
Applicants
  • UCB PHARMA S.A. [BE]/[BE] (AllExceptUS)
  • HEYWOOD, Sam, Philip [GB]/[GB] (UsOnly)
  • HUMPHREYS, David, Paul [GB]/[GB] (UsOnly)
Inventors
  • HEYWOOD, Sam, Philip
  • HUMPHREYS, David, Paul
Agents
  • THOMPSON, John
Priority Data
1005061.525.03.2010GB
1005062.325.03.2010GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) DISULFIDE STABILIZED DVD-LG MOLECULES
(FR) MOLÉCULES DE DVD-LG STABILISÉES PAR UN DISULFURE
Abstract
(EN)
The present disclosure provides a binding protein comprising: a polypeptide heavy chain comprising: VH1-(X1)n-VH2-CH (X2)y wherein VH1 is a first variable domain, VH2 is a second variable domain, CH is a constant domain, X1 represents an amino acid or peptide, X2 represents an Fc region, n is 0 or 1 and y is independently 1 or 2, and a polypeptide light chain comprising: VL1-(X1)n-VL2-C wherein VL1 is a first variable domain, VL2 is a second variable domain, C is a constant domain, X1 represents an amino acid or peptide and n is 0 or 1, wherein the heavy chain and light chain are aligned such that VH1 and VL1 form a first binding domain, and VH2 and VL2 form a second binding domain and wherein: there is a disulfide bond between VH1 and VL1, and/or there is a disulfide bond between VH2 and VL2, and use thereof in treatment.
(FR)
L'invention concerne une protéine de liaison qui comprend: une chaîne lourde polypeptidique comprenant VH1-(X1)n-VH2-CH (X2)y, VH1 représentant un premier domaine variable, VH2 représentant un deuxième domaine variable, CH représentant un domaine constant, X1 représentant un acide aminé ou un peptide, X2 représentant une région Fc, n représentant 0 ou 1 et y représentant indépendamment 1 ou 2; et une chaîne légère polypeptidique comprenant VL1-(X1)n-VL2-C, VL1 représentant un premier domaine variable, VL2 représentant un deuxième domaine variable, C représentant un domaine constant, X1 représentant un acide aminé ou un peptide et n représentant 0 ou 1. La chaîne lourde et la chaîne légère sont alignées de sorte que VH1 et VL1 forment un premier domaine de liaison, et VH2 et VL2 forment un deuxième domaine de liaison; et une liaison disulfure est présente entre VH1 et VL1, et/ou une liaison disulfure est présente entre VH2 et VL2. L'invention concerne aussi l'utilisation thérapeutique de cette protéine.
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