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1. WO2011110859 - PYRIMIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF RESPIRATORY DISEASES SUCH AS COPD

Publication Number WO/2011/110859
Publication Date 15.09.2011
International Application No. PCT/GB2011/050478
International Filing Date 10.03.2011
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1
Drugs for disorders of the alimentary tract or the digestive system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11
Drugs for disorders of the respiratory system
C07D 487/04 (2006.01)
A61K 31/519 (2006.01)
A61P 1/00 (2006.01)
A61P 11/00 (2006.01)
CPC
A61K 31/519
A61K 31/52
C07B 2200/07
C07D 487/04
Applicants
  • CHIESI FARMACEUTICI S.p.A. [IT/IT]; Via Palermo, 26/A I-43100 Parma, IT (AllExceptUS)
  • EDWARDS, Christine [GB/GB]; GB (UsOnly)
  • KULAGOWSKI, Janusz [GB/GB]; GB (UsOnly)
  • FINCH, Harry [GB/GB]; GB (UsOnly)
Inventors
  • EDWARDS, Christine; GB
  • KULAGOWSKI, Janusz; GB
  • FINCH, Harry; GB
Agents
  • MINOJA, Fabrizio; BIANCHETTI BRACCO MINOJA S.r.l. Via Plinio, 63 I-20129 Milano, IT
Priority Data
1004179.612.03.2010GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PYRIMIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF RESPIRATORY DISEASES SUCH AS COPD
(FR) DÉRIVÉS DE PYRIMIDINE ET LEUR UTILISATION DANS LE TRAITEMENT DE MALADIES RESPIRATOIRES TELLES QUE LA MALADIE PULMONAIRE OBSTRUCTIVE CHRONIQUE (MPOC)
Abstract
(EN)
Compounds of formula (I) are inhibitors of neutrophil elastase, wherein A is C-R1 or N; -X1-X2- is CR15=N- or -NR19-CO-; and R1-R6, R15 and R16are as defined in the claims.
(FR)
L'invention concerne des composés de formule (I) utilisés comme inhibiteurs de l'élastase neutrophile. Dans ladite formule, A est C-R1 ou N; -X1-X2- est CR15=N- ou -NR19-CO-; et R1-R6, R15 et R16 sont tels que définis dans les revendications.
Latest bibliographic data on file with the International Bureau