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59. (WO2011104565) CAMELID ANTIBODIES FOR USE IN COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2011/104565 International Application No.: PCT/GB2011/050382
Publication Date: 01.09.2011 International Filing Date: 25.02.2011
IPC:
C07K 16/06 (2006.01) ,C07K 16/18 (2006.01) ,C07K 16/28 (2006.01) ,C07K 16/30 (2006.01) ,C07K 16/04 (2006.01) ,A61K 47/48 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
06
from serum
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
30
from tumour cells
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
04
from milk
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
48
the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
Applicants:
JASSIM, Sabah Abdel Amir [GB/GB]; GB (UsOnly)
AL JUBOORI, Zeyad Ahmed Shabeeb [IQ/IQ]; IQ (UsOnly)
ABDULAMIR, Ahmed Sahib [IQ/IQ]; IQ (UsOnly)
ARAB BIOTECHNOLOGY COMPANY [AE/AE]; Flat G1 Al Khadem Building University City Road Sharjah, AE (AllExceptUS)
Inventors:
JASSIM, Sabah Abdel Amir; GB
AL JUBOORI, Zeyad Ahmed Shabeeb; IQ
ABDULAMIR, Ahmed Sahib; IQ
Agent:
McQUEEN, Andrew Peter; 1 St Augustines Place Bristol BS1 4UD, GB
Priority Data:
1003198.725.02.2010GB
Title (EN) CAMELID ANTIBODIES FOR USE IN COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER
(FR) ANTICORPS DE CAMÉLIDÉS DESTINÉS À ÊTRE UTILISÉS DANS DES COMPOSITIONS ET PROCÉDÉS POUR LE TRAITEMENT DU CANCER
Abstract:
(EN) A method for producing immunoglobulin that specifically binds to cancer cells, said method comprising immunising a camelid with tumour associated antigen purified from cancer cells by acid elution and purifying tumour associated antigen-specific immunoglobulin from a body fluid of said camelid. Also provided are cancer cell-specific camelid immunoglobulins produced by the method of the invention and methods for treating or preventing cancer which comprise administration of said cancer cell-specific immunoglobulins, or immunotoxins derived therefrom.
(FR) La présente invention concerne un procédé pour la production d'immunoglobuline de liaison spécifique aux cellules cancéreuses, ledit procédé comprenant l'immunisation d'un camélidé avec un antigène associé aux tumeurs purifié dérivé de cellules cancéreuses par élution à l'acide et la purification d'immunoglobuline spécifique de l'antigène associé aux tumeurs dérivé d'un liquide organique dudit camélidé. L'invention concerne également des immunoglobulines de camélidés spécifiques des cellules cancéreuses produites par le procédé selon l'invention et des procédés pour le traitement ou la prévention du cancer comprenant l'administration desdites immunoglobulines spécifiques des cellules cancéreuses, ou des immunotoxines qui en sont dérivées.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)