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1. WO2011104340 - THIENOPYRIMIDINES CONTAINING A SUBSTITUTED ALKYL GROUP FOR PHARMACEUTICAL COMPOSITIONS

Publication Number WO/2011/104340
Publication Date 01.09.2011
International Application No. PCT/EP2011/052813
International Filing Date 25.02.2011
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
495
Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
38
having sulfur as a ring hetero atom
381
having five-membered rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
C07D 495/04 (2006.01)
A61K 31/381 (2006.01)
A61P 9/00 (2006.01)
CPC
C07D 495/04
Applicants
  • BOEHRINGER INGELHEIM INTERNATIONAL GMBH [DE/DE]; Binger Str. 173 55216 Ingelheim Am Rhein, DE (AllExceptUS)
  • HECKEL, Armin [DE/DE]; DE (UsOnly)
  • HIMMELSBACH, Frank [DE/DE]; DE (UsOnly)
  • KLEY, Joerg [DE/DE]; DE (UsOnly)
  • LEHMANN-LINTZ, Thorsten [DE/DE]; DE (UsOnly)
  • REDEMANN, Norbert [DE/DE]; DE (UsOnly)
  • SAUER, Achim [DE/DE]; DE (UsOnly)
  • THOMAS, Leo [DE/DE]; DE (UsOnly)
  • WIEDENMAYER, Dieter [DE/DE]; DE (UsOnly)
  • BLACK, Phillip [GB/GB]; GB (UsOnly)
  • BLACKABY, Wesley [GB/GB]; GB (UsOnly)
  • LINNEY, Ian [GB/GB]; GB (UsOnly)
  • AUSTEN, Matthias [DE/DE]; DE (UsOnly)
  • DANILEWICZ, John [GB/GB]; GB (UsOnly)
  • SCHNEIDER, Martin [DE/DE]; DE (UsOnly)
  • SCHREITER, Kay [DE/DE]; DE (UsOnly)
Inventors
  • HECKEL, Armin; DE
  • HIMMELSBACH, Frank; DE
  • KLEY, Joerg; DE
  • LEHMANN-LINTZ, Thorsten; DE
  • REDEMANN, Norbert; DE
  • SAUER, Achim; DE
  • THOMAS, Leo; DE
  • WIEDENMAYER, Dieter; DE
  • BLACK, Phillip; GB
  • BLACKABY, Wesley; GB
  • LINNEY, Ian; GB
  • AUSTEN, Matthias; DE
  • DANILEWICZ, John; GB
  • SCHNEIDER, Martin; DE
  • SCHREITER, Kay; DE
Agents
  • HAMMANN, Heinz; Boehringer Ingelheim GmbH Corporate Patents Binger Str. 173 55216 Ingelheim Am Rhein, DE
Priority Data
10154930.126.02.2010EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) THIENOPYRIMIDINES CONTAINING A SUBSTITUTED ALKYL GROUP FOR PHARMACEUTICAL COMPOSITIONS
(FR) THIÉNOPYRIMIDINES CONTENANT UN GROUPE ALKYLE SUBSTITUÉ POUR DES COMPOSITIONS PHARMACEUTIQUES
Abstract
(EN)
The present invention relates to novel thienopyhmidine compounds of general formula pharmaceutical compositions comprising these compounds and their therapeutic use for the prophylaxis and/or treatment of diseases which can be influenced by the inhibition of the kinase activity of Mnk1 and/or Mnk2 (Mnk2a or Mnk2b) and/or variants thereof.
(FR)
La présente invention porte sur de nouveaux composés thiénopyrimidines représentés par la formule générale, sur des compositions pharmaceutiques comprenant ces composés et sur leur utilisation thérapeutique pour la prophylaxie et/ou le traitement de maladies qui peuvent être influencées par l'inhibition de l'activité de kinase de Mnk1 et/ou Mnk2 (Mnk2a ou Mnk2b) et/ou de variantes de celles-ci.
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