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1. WO2011104338 - HALOGEN OR CYANO SUBSTITUTED THIENO [2,3-D]PYRIMIDINES HAVING MNK1/MNK2 INHIBITING ACTIVITY FOR PHARMACEUTICAL COMPOSITIONS

Publication Number WO/2011/104338
Publication Date 01.09.2011
International Application No. PCT/EP2011/052811
International Filing Date 25.02.2011
IPC
C07D 495/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
495Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
A61K 31/519 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
A61P 3/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
A61P 3/06 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
06Antihyperlipidemics
A61P 3/10 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
10for hyperglycaemia, e.g. antidiabetics
A61P 13/12 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
12of the kidneys
CPC
A61K 31/519
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 11/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
06Antiasthmatics
A61P 13/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
12of the kidneys
A61P 19/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
Applicants
  • BOEHRINGER INGELHEIM INTERNATIONAL GMBH [DE]/[DE] (AllExceptUS)
  • HECKEL, Armin [DE]/[DE] (UsOnly)
  • HIMMELSBACH, Frank [DE]/[DE] (UsOnly)
  • LEHMANN-LINTZ, Thorsten [DE]/[DE] (UsOnly)
  • REDEMANN, Norbert [DE]/[DE] (UsOnly)
  • SAUER, Achim [DE]/[DE] (UsOnly)
  • THOMAS, Leo [DE]/[DE] (UsOnly)
  • BLACK, Phillip [GB]/[GB] (UsOnly)
  • BLACKABY, Wesley [GB]/[GB] (UsOnly)
  • DANILEWICZ, John [GB]/[GB] (UsOnly)
  • LINNEY, Ian [GB]/[GB] (UsOnly)
  • AUSTEN, Matthias [DE]/[DE] (UsOnly)
  • SCHNEIDER, Martin [DE]/[DE] (UsOnly)
  • SCHREITER, Kay [DE]/[DE] (UsOnly)
Inventors
  • HECKEL, Armin
  • HIMMELSBACH, Frank
  • LEHMANN-LINTZ, Thorsten
  • REDEMANN, Norbert
  • SAUER, Achim
  • THOMAS, Leo
  • BLACK, Phillip
  • BLACKABY, Wesley
  • DANILEWICZ, John
  • LINNEY, Ian
  • AUSTEN, Matthias
  • SCHNEIDER, Martin
  • SCHREITER, Kay
Agents
  • HAMMANN, Heinz
Priority Data
10154928.526.02.2010EP
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) HALOGEN OR CYANO SUBSTITUTED THIENO [2,3-D]PYRIMIDINES HAVING MNK1/MNK2 INHIBITING ACTIVITY FOR PHARMACEUTICAL COMPOSITIONS
(FR) THIÉNO[2,3-D]PYRIMIDINES SUBSTITUÉES PAR HALOGÈNE OU CYANO AYANT UNE ACTIVITÉ D'INHIBITION DE MNK1/MNK2 POUR DES COMPOSITIONS PHARMACEUTIQUES
Abstract
(EN) The present invention relates to novel thienopyhmidine compounds of general formula (I), pharmaceutical compositions comprising these compounds and their therapeutic use for the prophylaxis and/or treatment of diseases which can be influenced by the inhibition of the kinase activity of Mnk1 and/or Mnk2 (Mnk2a or Mnk2b) and/or variants thereof.
(FR) La présente invention porte sur de nouveaux composés thiénopyrimidines représentés par la formule générale (I), sur des compositions pharmaceutiques comprenant ces composés et sur leur utilisation thérapeutique pour la prophylaxie et/ou le traitement de maladies qui peuvent être influencées par l'inhibition de l'activité de kinase de Mnk1 et/ou Mnk2 (Mnk2a or Mnk2b) et/ou de variantes de celles-ci.
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