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1. (WO2011098746) CRYSTALLINE ACID ADDITION SALTS OF ( 5R) -ENANTI0MER OF PIOGLITAZONE
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2011/098746 International Application No.: PCT/GB2010/050200
Publication Date: 18.08.2011 International Filing Date: 09.02.2010
IPC:
C07D 417/12 (2006.01) ,A61K 31/427 (2006.01) ,A61P 11/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
425
Thiazoles
427
not condensed and containing further heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11
Drugs for disorders of the respiratory system
Applicants:
VAN NIEL, Monique Bodil [NL/GB]; GB (UsOnly)
FORREST, Andrew [GB/GB]; GB (UsOnly)
FOX, Craig [GB/GB]; GB (UsOnly)
SAJAD, Mohammed [GB/GB]; GB (UsOnly)
FINCH, Harry [GB/GB]; GB (UsOnly)
PULMAGEN THERAPEUTICS (INFLAMMATION) LIMITED [GB/GB]; Fulmer Hall Windmill Road Fulmer Slough Berkshire SL3 6HD, GB (AllExceptUS)
Inventors:
VAN NIEL, Monique Bodil; GB
FORREST, Andrew; GB
FOX, Craig; GB
SAJAD, Mohammed; GB
FINCH, Harry; GB
Agent:
SIMCOX, Michael; D Young & Co LLP 120 Holborn London EC1N 2DY, GB
Priority Data:
Title (EN) CRYSTALLINE ACID ADDITION SALTS OF ( 5R) -ENANTI0MER OF PIOGLITAZONE
(FR) SELS D'ADDITION ACIDE CRISTALLINS DE L'ÉNANTIOMÈRE (5R) DE LA PIOGLITAZONE
Abstract:
(EN) A crystalline acid addition salt of 5R-pioglitazone, said salt being selected from the hydrochloride, hydrobromide, (-)-O,O'-dibenzoyl-L-tartrate, phosphate, hydroxy-ethanesulfonic acid and the naphthalene-1,5-disulfonic acid (2:1 ) salts thereof, wherein the naphthalene-1,5-disulfonic acid salt contains 2 molecules of (5R)-5-{4-[2- (5-ethylpyrϊdin-2-yl)ethoxy]benzyI}-1,3-thiazoIidine-2,4-dione for each molecule of naphthalene-1,5-disulfonic acid.
(FR) L'invention concerne un sel d'addition acide cristallin de 5R-pioglitazone, ledit sel étant choisi parmi ses sels de chlorhydrate, de bromhydrate, de L-tartrate de (-)-O,O'-dibenzoyle, de phosphate, de l'acide hydroxy-éthanesulfonique et de l'acide naphtalène-1,5-disulfonique (2:1), le sel de l'acide naphtalène-1,5-disulfonique contenant 2 molécules de (5R)-5-{4-[2-(5-éthylpyridin-2-yl)éthoxy]benzyl}-1,3-thiazolidine-2,4-dione pour chaque molécule d'acide naphtalène-1,5-disulfonique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)