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1. WO2011098519 - HOMOARGININE AS A BIOMARKER FOR THE RISK OF MORTALITY

Publication Number WO/2011/098519
Publication Date 18.08.2011
International Application No. PCT/EP2011/051957
International Filing Date 10.02.2011
IPC
A23L 1/305 2006.1
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D91; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
1Foods or foodstuffs; Their preparation or treatment
29Modifying nutritive qualities of foods; Dietetic products
30containing additives
305Amino acids, peptides or proteins 
A61K 31/198 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19Carboxylic acids, e.g. valproic acid
195having an amino group
197the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid (GABA), beta-alanine, epsilon-aminocaproic acid, pantothenic acid
198Alpha-amino acids, e.g. alanine, edetic acid (EDTA)
G01N 33/68 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
CPC
A23L 33/175
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A23B - A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT
33Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
10using additives
17Amino acids, peptides or proteins
175Amino acids
A61K 31/198
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
19Carboxylic acids, e.g. valproic acid
195having an amino group
197the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
198Alpha-aminoacids, e.g. alanine, edetic acids [EDTA],
G01N 2800/32
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2800Detection or diagnosis of diseases
32Cardiovascular disorders
G01N 2800/52
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2800Detection or diagnosis of diseases
52Predicting or monitoring the response to treatment; Prognosis
G01N 2800/56
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2800Detection or diagnosis of diseases
56Staging of a disease; Further complications associated with the disease
G01N 33/50
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
Applicants
  • SYNLAB MEDIZINISCHES VERSORGUNGSZENTRUM HEIDELBERG GMBH [DE]/[DE] (AllExceptUS)
  • MAERZ, Winfried [DE]/[DE] (UsOnly)
  • MEINITZER, Andreas [AT]/[AT] (UsOnly)
  • DRECHSLER, Christiane [DE]/[DE] (UsOnly)
  • PILZ, Stefan [AT]/[AT] (UsOnly)
  • KRANE, Vera [DE]/[DE] (UsOnly)
  • WANNER, Christoph [DE]/[DE] (UsOnly)
Inventors
  • MAERZ, Winfried
  • MEINITZER, Andreas
  • DRECHSLER, Christiane
  • PILZ, Stefan
  • KRANE, Vera
  • WANNER, Christoph
Agents
  • BÜCHEL, Edwin
Priority Data
10153545.812.02.2010EP
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) HOMOARGININE AS A BIOMARKER FOR THE RISK OF MORTALITY
(FR) HOMOARGININE UTILISÉE EN TANT QUE BIOMARQUEUR DU RISQUE DE MORTALITÉ
Abstract
(EN) The present invention relates to the field of laboratory diagnostics. Specifically, means and methods for determining the risk of mortality in a patient based on homoarginine and to reduce the risk of mortality by administration of homoarginine are disclosed. Moreover, the present invention relates to the use of homoarginine for the preparation of a medicament for the treatment of a patient having an increased risk of mortality caused by stroke or a cardiac cause. Furthermore, the present application relates to a pharmaceutical composition comprising homoarginine and a composition for foodstuff supplement comprising homoarginine.
(FR) La présente invention concerne le domaine des diagnostics de laboratoire. La présente invention concerne, plus précisément, des moyens et des méthodes permettant de déterminer, sur la base de l'homoarginine, le risque de mortalité chez un patient, ainsi que de réduire le risque de mortalité grâce à l'administration d'homoarginine. La présente invention concerne, en outre, l'utilisation d'homoarginine en vue de la préparation d'un médicament permettant de traiter un patient souffrant d'un risque de mortalité accru du fait d'un AVC ou d'un problème cardiaque. La présente invention concerne, également, une composition pharmaceutique contenant de l'homoarginine et une composition de type complément alimentaire contenant de l'homoarginine.
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